Role of spiramycin in prevention of fetal toxoplasmosis
![Thumbnail](/xmlui/bitstream/handle/20.500.12511/3188/Arslan-Ferhat%202016.pdf.jpg?sequence=5&isAllowed=y)
View/ Open
Access
info:eu-repo/semantics/openAccessDate
2016Author
Avcı, Muhittin EftalArslan, Ferhat
Çiftci, Şinasi
Ekiz, Ali
Tüten, Abdullah
Yıldırım, Gökhan
Madazlı, Rıza
Metadata
Show full item recordCitation
Avcı, M. E., Arslan, F., Çiftci, Ş., Ekiz, A., Tüten, A., Yıldırım, G. ... Madazlı, R. (2016). Role of spiramycin in prevention of fetal toxoplasmosis. Journal Of Maternal-Fetal & Neonatal Medicine, 29(13), 2073-2076. https://dx.doi.org/10.3109/14767058.2015.1074998Abstract
Objective: The aim of this study is to evaluate the efficacy of spiramycin in prevention of mother-to-child transmission of Toxoplasma gondii infection. Methods: Patients within first trimester of their pregnancy with Toxoplasma IgM positivity (>0.65 index, ELISA, VIDAS) and IgG positivity (>8 IU/ml), who had low IgG avidity (<0.50 index, ELISA, Architet) were considered as having acute toxoplasmosis. These patients who had amniocentesis at the 19th-21st week of pregnancy were examined for the detection of Toxoplasma DNA. Detailed ultrasonographic examinations performed between the 20th and 24th gestational weeks and the mothers and babies were followed for at least one year. Results: Out of 61 patients, 55 (90.2%) had received Spy prophylaxis while 6 (9.8%) cases refused Spy prophylaxis. Toxoplasma PCR test was found to be positive in amniotic fluid of 4 (6.6%) patients obtained by amniocentesis at the 19th-21st week of pregnancy. All four of these patients had refused Spy prophylaxis had positive Toxoplasma PCR in amniotic fluid (p<0.01). Conclusion: Our results seem to encourage the use of spiramycin in women with toxoplasmosis during pregnancy.
WoS Q Kategorisi
Q3xmlui.dri2xhtml.METS-1.0.item-scopusquality
Q2Source
Journal Of Maternal-Fetal & Neonatal MedicineVolume
29Issue
13Collections
- Makale Koleksiyonu [3790]
- PubMed İndeksli Yayınlar Koleksiyonu [4251]
- Scopus İndeksli Yayınlar Koleksiyonu [6601]
- WoS İndeksli Yayınlar Koleksiyonu [6677]