The neuroprotective effect of coumaric acid on spinal cord ischemia/reperfusion injury in rats
View/ Open
Access
info:eu-repo/semantics/embargoedAccessDate
2015Author
Güven, MustafaŞehitoğlu, Müşerref Hilal
Yüksel, Yasemin
Tokmak, Mehmet
Bozkurt Aras, Adem
Akman, Tarık Muhammed
Gölge, Umut Hatay
Karavelioğlu, Ergün
Bal, Ercan
Çoşar, Murat
Metadata
Show full item recordCitation
Güven, M., Şehitoğlu, M. H., Yüksel, Y., Tokmak, M., Bozkurt Aras, A., Akman, T. M. ... Çoşar, M. (2015). The neuroprotective effect of coumaric acid on spinal cord ischemia/reperfusion injury in rats. Inflammation, 38(5), 1986-1995. https://dx.doi.org/10.1007/s10753-015-0179-0Abstract
The main causes of spinal cord ischemia are a variety of vascular pathologies causing acute arterial occlusions. We investigated neuroprotective effects of coumaric acid on spinal cord ischemia injury in rats. Rats were divided randomly into four groups of eight animals as follows: control, ischemia, ischemia + coumaric acid, and ischemia + methylprednisolone. In the control group, only a laparotomy was performed. In all other groups, the spinal cord ischemia was performed by the infrarenal aorta cross-clamping model. Levels of malondialdehyde and nuclear respiratory factor 1 were analyzed, as were the activity of superoxide dismutase. Histopathological and immunohistochemical evaluations were performed. Neurological evaluation was performed with the Tarlov scoring system. The ischemia + coumaric acid group was compared with the ischemia group, and a significant decrease in malondialdehyde and levels was observed. Nuclear respiratory factor 1 level and superoxide dismutase activity of the ischemia + coumaric acid group were significantly higher than in the ischemia group. In histopathological samples, the ischemia + coumaric acid group is compared with the ischemia group, and there was a significant increase in numbers of normal neurons. In immunohistochemical staining, hypoxia-inducible factor-1 alpha and NF-kappa B immunopositive neurons were significantly decreased in the ischemia + coumaric acid group compared with that in the ischemia group. The neurological deficit scores of the ischemia + coumaric acid group were significantly higher than the ischemia group at 24 h. Our results revealed for the first time that coumaric acid exhibits meaningful neuroprotective activity following ischemia-reperfusion injury of the spinal cord.
WoS Q Kategorisi
Q3xmlui.dri2xhtml.METS-1.0.item-scopusquality
Q2Source
InflammationVolume
38Issue
5Collections
- Makale Koleksiyonu [3642]
- PubMed İndeksli Yayınlar Koleksiyonu [4039]
- Scopus İndeksli Yayınlar Koleksiyonu [6271]
- WoS İndeksli Yayınlar Koleksiyonu [6416]