dc.contributor.author | İnanç Balkan, İlker | |
dc.contributor.author | Batırel, Ayşe | |
dc.contributor.author | Karabay, Oğuz | |
dc.contributor.author | Aǧalar, Canan | |
dc.contributor.author | Akalın, Şerife | |
dc.contributor.author | Alıcı, Özlem | |
dc.contributor.author | Alp, Emine | |
dc.contributor.author | Altay, Fatma Aybala | |
dc.contributor.author | Altın, Nilgün | |
dc.contributor.author | Arslan, Ferhat | |
dc.contributor.author | Aslan, Turan | |
dc.contributor.author | Bekiroğlu, Nural | |
dc.contributor.author | Cesur, Salih | |
dc.contributor.author | Doǧan Çelik, Aygül | |
dc.contributor.author | Doǧan, Mustafa | |
dc.contributor.author | Durdu, Bülent | |
dc.contributor.author | Duygu, Fazilet | |
dc.contributor.author | Engin, Aynur | |
dc.contributor.author | Öztürk Engin, Derya | |
dc.contributor.author | Gönen, İbak | |
dc.contributor.author | Güçlü, Ertuğrul | |
dc.contributor.author | Güven, Tümer | |
dc.contributor.author | Hatipoǧlu, Çiǧdem | |
dc.contributor.author | Hoşoǧlu, Salih | |
dc.contributor.author | Karahocagil, Mustafa Kasım | |
dc.contributor.author | Ulu Kılıç, Ayşegül | |
dc.contributor.author | Örmen, Bahar | |
dc.contributor.author | Özdemir, Davut | |
dc.contributor.author | Özer, Serdar | |
dc.contributor.author | Öztoprak, Nefise | |
dc.contributor.author | Sezak, Nur Banu | |
dc.contributor.author | Turhan, Vedat | |
dc.contributor.author | Türker, Nesrin | |
dc.contributor.author | Yılmaz, Hava | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:56:24Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:56:24Z | |
dc.date.issued | 2015 | en_US |
dc.identifier.citation | İnanç Balkan, İ., Batırel, A., Karabay, O., Aǧalar, C., Akalın, Ş., Alıcı, Ö. ... Yılmaz, H. (2015). Comparison of colistin monotherapy and non-colistin combinations in the treatment of multi-drug resistant Acinetobacter spp. bloodstream infections: A multicenter retrospective analysis. Indian Journal of Pharmacology, 47(1), 95-100. https://dx.doi.org/10.4103/0253-7613.150383 | en_US |
dc.identifier.issn | 0253-7613 | |
dc.identifier.issn | 1998-3751 | |
dc.identifier.uri | https://dx.doi.org/10.4103/0253-7613.150383 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/2693 | |
dc.description | WOS: 000349144300018 | en_US |
dc.description | PubMed ID: 25821319 | en_US |
dc.description.abstract | Objectives: To compare the efficacy of colistin (COL) monotherapy versus non-COL based combinations in the treatment of bloodstream infections (BSIs) due to multidrug resistant Acinetobacter spp.(MDR-A) . Materials and Methods: Retrospective data of 107 MDR-A BSI cases from 27 tertiary centers in Turkey were included. Primary End-Point: 14-day mortality. Secondary End-Points: Microbial eradication and clinical improvement. Results: Thirty-six patients in the COL monotherapy (CM) group and 71 in the non-COL based combinations (NCC) group were included in the study. Mean age was 59.98 20 years (range: 18-89) and 50.5% were male. Median duration of follow-up was 40 days (range: 9-297). The 14-day survival rates were 52.8% in CM and 47.23% in NCC group (P = 0.36). Microbiological eradication was achieved in 69% of CM and 83% of NCC group (P = 0.13). Treatment failure was detected in 22.9% of cases in both CM and NCC groups. Univariate analysis revealed that mean age (P = 0.001), Charlson comorbidity index (P = 0.03), duration of hospital stay before MDR-A BSI (P = 0.04), Pitt bacteremia score (P = 0.043) and Acute Physiology and Chronic Health Evaluation II score (P = 0.05) were significant in terms of 14-day mortality. Advanced age (P = 0.01) and duration of hospital stay before MDR-A BSI (P = 0.04) were independently associated with 14-day mortality in multivariate analysis. Conclusion: No significant difference was detected between CM and non-COL based combinations in the treatment of MDR-A BSIs in terms of efficacy and 14-day mortality. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Medknow Publications | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Blood Stream Infection | en_US |
dc.subject | Colistin | en_US |
dc.subject | Monotherapy | en_US |
dc.subject | Multi Drug Resistant Acinetobacter Spp | en_US |
dc.title | Comparison of colistin monotherapy and non-colistin combinations in the treatment of multi-drug resistant Acinetobacter spp. bloodstream infections: A Multicenter retrospective analysis | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Indian Journal of Pharmacology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0001-8945-2385 | en_US |
dc.identifier.volume | 47 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 95 | en_US |
dc.identifier.endpage | 100 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.4103/0253-7613.150383 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.scopusquality | Q3 | en_US |