dc.contributor.author | Akın, Mehmet | |
dc.contributor.author | Turgut, Sebahat | |
dc.contributor.author | Ayada, Ceylan | |
dc.contributor.author | Polat, Yusuf | |
dc.contributor.author | Işık Balcı, Yasemin | |
dc.contributor.author | Erdoğan, Fırat | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:56:04Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:56:04Z | |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | Akın, M., Turgut, S., Ayada, C., Polat, Y., Işık Balcı, Y. ve Erdoğan, F. (2011). Relation between 3435C > T multidrug resistance 1 gene polymorphism with high dose methylprednisolone treatment of childhood acute idiopathic thrombocytopenic purpura. Gene, 487(1), 80-83. https://dx.doi.org/10.1016/j.gene.2011.06.019 | en_US |
dc.identifier.issn | 0378-1119 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.gene.2011.06.019 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/2559 | |
dc.description | WOS: 000296823500011 | en_US |
dc.description | PubMed ID: 21718764 | en_US |
dc.description.abstract | The current study was conducted to assess 3435C>T multidrug resistance 1 gene polymorphism and the efficacy of high dose methylprednisolone (HDMP) in childhood acute idiopathic thrombocytopenic purpura patients. Methods: A total of 31 childhood acute Idiopathic thrombocytopenic purpura patients (17 females, 14 males) between the ages of 2 and 16 years of age were included in the study. High-dose methylprednisolone was given at a dose of 30 mg/kg/day for 3 days and 20 mg/kg/day for 4 days, consecutively and intravenously. Polymerase chain reaction-restriction fragment length polymorphism was used for the detection of C3435T single nucleotide polymorphism. Fragments obtained were 238 bp to T/T genotype, 172 bp and 60 bp fragments to the C/C genotype, and 238 bp, 172 bp and 60 bp to the C/T genotype. Results: The distribution of CC, CT, and TT genotypes were 19.0%, 61.3%, and 19.4%, respectively. Both allele frequencies of C and T were the same -50%. There was no significant difference in genotype and allele distribution between the patients with LIP and the control group (chi(2)=0.84 p = 0.65, chi(2)=0.2 p = 0.63, respectively). There were no significant differences in age, gender, and pre- and post-treatment platelet counts between CC, CT, and TT genotypes of the MDR gene. Response to treatment shows no significant difference between genotype and allele groups. Conclusion: In our study, there was no difference in the HDMP treatment response between MDR1 gene genotypes. However, it should be noted that this study includes a small group of patients. Our data should therefore be considered preliminary, awaiting further confirmatory studies on an expanded patient base. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | MDR1 | en_US |
dc.subject | Idiopathic Thrombocytopenic Purpura | en_US |
dc.subject | High Dose Methylprednisolone | en_US |
dc.title | Relation between 3435C > T multidrug resistance 1 gene polymorphism with high dose methylprednisolone treatment of childhood acute idiopathic thrombocytopenic purpura | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Gene | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-6299-7067 | en_US |
dc.identifier.volume | 487 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 80 | en_US |
dc.identifier.endpage | 83 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.gene.2011.06.019 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.scopusquality | Q1 | en_US |