dc.contributor.author | Haider, Lukas | |
dc.contributor.author | Mandorfer, Mattias | |
dc.contributor.author | Güngören, Fatma Zeynep | |
dc.contributor.author | Reiberger, Thomas | |
dc.contributor.author | Bastati, Nina | |
dc.contributor.author | Hodge, Jacqueline C. | |
dc.contributor.author | Chromy, David | |
dc.contributor.author | Trauner, Michael | |
dc.contributor.author | Herold, Christian | |
dc.contributor.author | Peck-Radosavljevic, Markus | |
dc.contributor.author | Ba-Ssalamah, Ahmed | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:51:34Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:51:34Z | |
dc.date.issued | 2018 | en_US |
dc.identifier.citation | Haider, L., Mandorfer, M., Güngören, F. Z., Reiberger, T., Bastati, N., Hodge, J. ... Ba-Ssalamah, A. (2018). Noninvasive monitoring of liver disease regression after hepatitis C eradication using gadoxetic acid-enhanced MRI. Contrast Media & Molecular Imaging. https://dx.doi.org/10.1155/2018/8489709 | en_US |
dc.identifier.issn | 1555-4309 | |
dc.identifier.issn | 1555-4317 | |
dc.identifier.uri | https://dx.doi.org/10.1155/2018/8489709 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/2243 | |
dc.description | WOS: 000439796100001 | en_US |
dc.description | PubMed ID: 30116164 | en_US |
dc.description.abstract | We evaluated changes in relative liver enhancement (RLE) obtained by gadoxetic acid-enhanced MRI (GA-MRI) in the hepatobiliary phase and changes in splenic volume (SV) after hepatitis C virus (HCV) eradication as well as their predictive value for the development of (further) hepatic decompensation during follow-up. This retrospective study comprised 31 consecutive patients with HCV-induced advanced chronic liver disease who underwent GA-MRI before and after successful interferon-free treatment, as well as a cohort of 14 untreated chronic HCV-patients with paired GA-MRI. RLE increased by 66% (20%-94%; P <0.001) from pre- to posttreatment, while SV decreased by -16% (-28% to -8%; P <0.001). However, SV increased in 16% (5/31) of patients, the identical subjects who showed a decrease in RLE (GA-MRI-nonresponse). We observed an inverse correlation between the changes in RLE and SV (rho =-0.608; P <0.001). In the untreated patients, there was a decrease in RLE by -11% (-25% to -3%; P = 0.019) and an increase in SV by 23% (7%-43%; P = 0.004) (both P <0.001 versus treated patients). Interestingly, GA-MRI-nonresponse was associated with a substantially increased risk of (further) hepatic decompensation 2 years after the end of treatment: 80% versus 8%; P < 0.001. GA-MRI might distinguish between individuals at low and high risk of (further) hepatic decompensation (GA-MRI-nonresponse) after HCV eradication. This could allow for individualized surveillance strategies. | en_US |
dc.description.sponsorship | This study has received funding by Medical Scientific Fund of the Major of the City of Vienna (17035). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley-Hindawi | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Hepacivirus | en_US |
dc.subject | Hepatitis C | en_US |
dc.subject | Antivirals DAAs | en_US |
dc.subject | Acid-Enhanced | en_US |
dc.title | Noninvasive monitoring of liver disease regression after hepatitis C eradication using gadoxetic acid-enhanced MRI | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Contrast Media & Molecular Imaging | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-4437-9310 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1155/2018/8489709 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.scopusquality | Q2 | en_US |