dc.contributor.author | Öven Ustaalioğlu, Bala Başak | |
dc.contributor.author | Bilici, Ahmet | |
dc.contributor.author | Tilki, Metin | |
dc.contributor.author | Sürmelioğlu, Ali | |
dc.contributor.author | Erkol, Burçak | |
dc.contributor.author | Figen, Metin | |
dc.contributor.author | Uyar, Serab | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:50:14Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:50:14Z | |
dc.date.issued | 2018 | en_US |
dc.identifier.citation | Öven Ustaalioğlu, B. B., Bilici, A., Tilki, M., Sürmelioğlu, A., Erkol, B., Figen, M. ... Uyar, S. (2018). Capecitabine-cisplatin versus 5-fluorouracil/leucovorin in combination with radiotherapy for adjuvant therapy of lymph node positive locally advanced gastric cancer. Journal of Cancer Research and Therapeutics, 14(Supplement: 3), S736-S741. https://dx.doi.org/10.4103/0973-1482.183548 | en_US |
dc.identifier.issn | 0973-1482 | |
dc.identifier.issn | 1998-4138 | |
dc.identifier.uri | https://dx.doi.org/10.4103/0973-1482.183548 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/1922 | |
dc.description | WOS: 000445690700030 | en_US |
dc.description | PubMed ID: 30249896 | en_US |
dc.description.abstract | Aim of the Study: Although surgery is considered to be curative treatment, recurrence rates are high in gastric cancer. Adjuvant 5-fluorouracil (5-FU) based chemoradiotherapy has been shown to improve the prognosis. We compared tolerability and efficacy of the two different chemotherapy regimens; 5-FU/leucovorin (LV) versus cisplatin with capecitabine (XP) combined with radiotherapy (RT) in the adjuvant therapy of the lymph node positive locally advanced gastric cancer. Materials and Methods: Totally, 104 patients who underwent curative surgery with lymph node resection were evaluated, respectively. Patients were stratified two group based on the adjuvant chemoradiotherapy regimen. Group 1 (n = 46) received XP followed capecitabine with RT (XRT) then XP. Group 2 (n = 58) received 5-FU/LV combined with RT postoperatively. Two groups were compared based on clinicopathological parameters. Factors related with disease-free survival (DFS) and overall survival (OS) were analyzed. Results: Totally, 32 patients had recurrent disease, and there was no difference between two groups. While peritoneal metastasis was more common in XP arm, distant metastasis was commonly seen in 5-FU/LV arm. There was no significant difference between two groups in regard of Grade 3/4 toxicitis; hematologic toxicities were more in 5-FU/LV group than XP arm. In addition, dose modification because of toxicities were more frequent in 5-FU/LV arm (P = 0.003). For all groups, lymph node dissection type was related with DFS, surgical margin and recurrence were important for OS. Conclusion: XP-XRT regimen is well tolerated with lower toxicity compared the standard 5-FU/LV-RT. Although there is no difference with respect to outcome, patients with XP arm without the necessity of intravenous catheter admitted hospital less frequent than bolus5-FU/LV arm. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wolters Kluwer Medknow Publications | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | Adjuvant Chemoradiotherapy | en_US |
dc.subject | Capecitabine | en_US |
dc.subject | Gastric Cancer | en_US |
dc.subject | Lymph Node Positive | en_US |
dc.subject | 5-Fluorouracil / Leucovorin | en_US |
dc.title | Capecitabine-cisplatin versus 5-fluorouracil/leucovorin in combination with radiotherapy for adjuvant therapy of lymph node positive locally advanced gastric cancer | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Cancer Research and Therapeutics | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı | en_US |
dc.identifier.volume | 14 | en_US |
dc.identifier.issue | Supplement: 3 | en_US |
dc.identifier.startpage | S736 | en_US |
dc.identifier.endpage | S741 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.4103/0973-1482.183548 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.scopusquality | Q3 | en_US |