Etanercept-induced Crohn's disease in ankylosing spondylitis: A case report and review of the literature
Künye
Tolu, S., Rezvani, A., Hindioğlu, N. ve Korkmaz, M. (2018). Etanercept-induced Crohn's disease in ankylosing spondylitis: A case report and review of the literature. Rheumatology International, 38(11), 2157-2162. https://dx.doi.org/10.1007/s00296-018-4165-3Özet
Tumor necrosis factor (TNF)- is a cytokine that plays a well-established, key role as a central mediator of inflammation and immune regulation. TNF- and its receptors are suggested to play a critical role in a number of chronic inflammatory diseases, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis (AS), juvenile chronic arthritis, and inflammatory bowel disease (IBD). TNF- inhibitors are currently used in the treatment of these diseases. We report a 29-year-old male with AS who developed Crohn's disease while taking etanercept. Etanercept treatment was interrupted and a switch to a monoclonal antibody-based anti-TNF treatment using adalimumab was started, which induced a prompt improvement of the gastrointestinal symptoms. We indicate the immunodysregulatory and proinflammatory effects of etanercept and discuss the potential pathogenic mechanisms of the paradoxical effect of TNF- inhibitors. We also review the related literature on new-onset IBD following anti-TNF treatment for AS.