dc.contributor.author | Kılınç, Suna | |
dc.contributor.author | Atay, Enver | |
dc.contributor.author | Ceran, Ömer | |
dc.contributor.author | Atay, Zeynep | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:49:55Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:49:55Z | |
dc.date.issued | 2019 | en_US |
dc.identifier.citation | Kılınç, S., Atay, E., Ceran, Ö. ve Atay, Z. (2019). Evaluation of vitamin D status and its correlation with gonadal function in children at mini-puberty. Clinical Endocrinology, 90(1), 122-128. https://dx.doi.org/10.1111/cen.13856 | en_US |
dc.identifier.issn | 0300-0664 | |
dc.identifier.issn | 1365-2265 | |
dc.identifier.uri | https://dx.doi.org/10.1111/cen.13856 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/1815 | |
dc.description | WOS: 000453904100014 | en_US |
dc.description | PubMed ID: 30229999 | en_US |
dc.description.abstract | Context The effects of Vitamin D on reproductive function in adults have gained interest. Studies have demonstrated some associations. Hypothalamic-pituitary-gonadal axis is activated during the first 6 months of life, called as mini-puberty. This HPG activation is important for future gonadal function. There are no data regarding the association of gonadal hormones and 25(OH)D levels at mini-puberty. Demonstration of any association would form the basis for studies that will search for the effects of 25(OH)D on gonadal hormones at mini-puberty. Objective To characterize the associations between 25(OH)D levels and gonadal hormones at mini-puberty. Design Cross-sectional cohort analysis. Patient(s) or other participant(s) A total of 180 (94 boys and 86 girls) healthy appropriate-for-gestational-age neonates were included. Main outcome measure(s) 25(OH)D, LH, FSH, total testosterone, oestradiol, AMH and inhibin B levels were measured at postnatal 30-45 days. All infants were divided into three groups including vitamin D deficiency (<10 ng/mL), vitamin D insufficiency (10-20 ng/mL) and vitamin D sufficiency (>20 ng/mL). Correlations between vitamin D status and reproductive hormones were analysed. Result(s) Total testosterone level was higher (mean: 0.52 +/- 0.32 vs 0.26 +/- 0.2 ng/mL; P: 0.008) and inhibin B was lower in 25(OH)D deficient than sufficient girls (mean: 21.2 +/- 15.71 vs 53.25 +/- 47.25 pg/mL; P: 0.021). Conclusion(s) A modest effect of 25(OH)D was identified on total testosterone and inhibin B in girls at mini-puberty. The 25(OH)D may have an effect on gonadal function during early life. Randomized controlled trials could clarify the importance of vitamin D on gonadal hormones at mini-puberty. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | AMH | en_US |
dc.subject | Inhibin B | en_US |
dc.subject | Mini-Puberty | en_US |
dc.subject | Reproduction | en_US |
dc.subject | Sex Steroids | en_US |
dc.subject | Vitamin D | en_US |
dc.title | Evaluation of vitamin D status and its correlation with gonadal function in children at mini-puberty | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Clinical Endocrinology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-8968-4079 | en_US |
dc.authorid | 0000-0002-1044-6888 | en_US |
dc.identifier.volume | 90 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 122 | en_US |
dc.identifier.endpage | 128 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1111/cen.13856 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.scopusquality | Q1 | en_US |