dc.contributor.author | Babiloni, Claudio | |
dc.contributor.author | del Percio, Claudio | |
dc.contributor.author | Pascarelli, Maria Teresa | |
dc.contributor.author | Lizio, Roberta | |
dc.contributor.author | Noce, Giuseppe | |
dc.contributor.author | Lopez, Susanna | |
dc.contributor.author | Rizzo, Marco | |
dc.contributor.author | Ferri, Rafaele | |
dc.contributor.author | Soricelli, Andrea | |
dc.contributor.author | Nobili, Flavio | |
dc.contributor.author | Arnaldi, Dario | |
dc.contributor.author | Fama, Francesco | |
dc.contributor.author | Orzi, Francesco | |
dc.contributor.author | Buttinelli, Carla | |
dc.contributor.author | Giubilei, Franco | |
dc.contributor.author | Salvetti, Marco | |
dc.contributor.author | Cipollini, Virginia | |
dc.contributor.author | Franciotti, Raffaella | |
dc.contributor.author | Onofrj, Marco | |
dc.contributor.author | Stirpe, Paola | |
dc.contributor.author | Fuhr, Peter | |
dc.contributor.author | Gschwandtner, Ute | |
dc.contributor.author | Ransmayr, Gerhard | |
dc.contributor.author | Aarsland, Dag | |
dc.contributor.author | Parnetti, Lucilla | |
dc.contributor.author | Farotti, Lucia | |
dc.contributor.author | Marizzoni, Moira | |
dc.contributor.author | D'Antonio, Fabrizia | |
dc.contributor.author | De Lena, Carlo | |
dc.contributor.author | Güntekin, Bahar | |
dc.contributor.author | Hanoğlu, Lütfü | |
dc.contributor.author | Yener, Görsev | |
dc.contributor.author | Emek Savaş, Derya Durusu | |
dc.contributor.author | Triggiani, Antonio Ivano | |
dc.contributor.author | Taylor, John Paul | |
dc.contributor.author | McKeith, Ian | |
dc.contributor.author | Stocchi, Fabrizio | |
dc.contributor.author | Vacca, Laura | |
dc.contributor.author | Hampel, Harald | |
dc.contributor.author | Frisoni, Giovanni B. | |
dc.contributor.author | de Pandis, Maria Francesca | |
dc.contributor.author | Bonanni, Laura | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:49:35Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:49:35Z | |
dc.date.issued | 2019 | en_US |
dc.identifier.citation | Babiloni, C., del Percio, C., Pascarelli, M. T., Lizio, R.
Noce, G., Lopez, S. ... Bonanni, L. (2019). Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases. Neurobiology of Aging, 77, 112-127. https://dx.doi.org/10.1016/j.neurobiolaging.2019.01.013 | en_US |
dc.identifier.issn | 0197-4580 | |
dc.identifier.issn | 1558-1497 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.neurobiolaging.2019.01.013 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/1665 | |
dc.description | WOS: 000465302200012 | en_US |
dc.description | PubMed ID: 30797169 | en_US |
dc.description.abstract | Previous evidence has shown different resting-state eyes-closed electroencephalographic delta (<4 Hz) and alpha (8-10.5 Hz) source connectivity in subjects with dementia due to Alzheimer's (ADD) and Lewy body (DLB) diseases. The present study tested if the same differences may be observed in the prodromal stages of mild cognitive impairment (MCI). Here, clinical and resting-state eyes-closed electroencephalographic data in age-, gender-, and education-matched 30 ADMCI, 23 DLBMCI, and 30 healthy elderly (Nold) subjects were available in our international archive. Mini-Mental State Evaluation (MMSE) score was matched in the ADMCI and DLBMCI groups. The eLORETA freeware estimated delta and alpha source connectivity by the tool called lagged linear connectivity (LLC). Area under receiver operating characteristic curve (AUROCC) indexed the classification accuracy among individuals. Results showed that widespread interhemispheric and intrahemispheric LLC solutions in alpha sources were abnormally lower in both MCI groups compared with the Nold group, but with no differences were found between the 2 MCI groups. AUROCCs of LLC solutions in alpha sources exhibited significant accuracies (0.72-0.75) in the discrimination of Nold versus ADMCI-DLBMCI individuals, but not between the 2 MCI groups. These findings disclose similar abnormalities in ADMCI and DLBMCI patients as revealed by alpha source connectivity. It can be speculated that source connectivity mostly reflects common cholinergic impairment in prodromal state of both AD and DLB, before a substantial dopaminergic derangement in the dementia stage of DLB. | en_US |
dc.description.sponsorship | H2020 Marie S. Curie ITN-ETN project; H2020-TWINN-2015 project | en_US |
dc.description.sponsorship | The present study was developed based on the data of the informal European Consortium PDWAVES and European Consortium of Dementia with Lewy Body. The members and institutional affiliations of the Consortia are reported in the cover page of this article. The research activities of the Unit of Sapienza University of Rome were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title "BBDiag" (http://bbdiagitn-etn.eu/) and the H2020-TWINN-2015 project with the short title "SynaNet" (https://www.synanet2020.com/). The authors thank Mrs. Jessica Janson and Mrs. Marina Selivanova for their support to those activities in the framework of the BBDiag project. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Science Inc | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Functional Brain Connectivity | en_US |
dc.subject | Resting State EEG Rhythms | en_US |
dc.subject | Mild Cognitive Impairment Due To | en_US |
dc.subject | Alzheimer's Disease (ADMCI) | en_US |
dc.subject | Mild Cognitive Impairment Due To Dementia With Lewy Body (DLBMCI) | en_US |
dc.title | Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Neurobiology of Aging | en_US |
dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-0860-0524 | en_US |
dc.authorid | 0000-0003-4292-5717 | en_US |
dc.identifier.volume | 77 | en_US |
dc.identifier.startpage | 112 | en_US |
dc.identifier.endpage | 127 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.neurobiolaging.2019.01.013 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.scopusquality | Q1 | en_US |