Hepatosplenomegaly and pernicious anaemia

Abstract

Sir,Pernicious anaemia (PA) is the end stage of atrophic gastritiswhich results in the loss of parietal cells in the fundus and bodyof the stomach. Loss of parietal cells is associated with the failureof intrinsic factor production and results in vitamin B12 deficiencyand megaloblastic anaemia. Only two cases of splenomegalycoexisting with PA have been reported, but both splenomegaly andhepatomegaly has not been reported yet [1,2]. In this report, weaimed to describe a patient with hepatosplenomegaly due to PA.To the best of our knowledge this is the first documented case ofhepatosplenomegaly due to PA and totally resolved by vitamin B12therapy.