dc.contributor.author | Babür Güler, Gamze | |
dc.contributor.author | Güler, Ekrem | |
dc.contributor.author | Hatipoğlu, Suzan | |
dc.contributor.author | Güneş, Hacı Murat | |
dc.contributor.author | Geçmen, Çetin | |
dc.contributor.author | Demir, Gültekin Günhan | |
dc.contributor.author | Barutçu, İrfan | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:37:04Z | |
dc.date.available | 10.07.201910:49:14 | |
dc.date.available | 2019-07-10T19:37:04Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Babür Güler, G., Güler, E., Hatipoğlu, S., Güneş, H. M., Geçmen, Ç., Demir, G. G. ... Barutçu, İ. (2016). Assessment of 25-OH vitamin D levels and abnormal blood pressure response in female patients with cardiac syndrome X. Anatolian Journal of Cardiology, 16(12), 961-966. | en_US |
dc.identifier.issn | 2149-2263 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/1323 | |
dc.identifier.uri | https://dx.doi.org/10.14744/AnatolJCardiol.2016.6862 | |
dc.description.abstract | Objective: Vitamin D deficiency is associated with coronary artery disease, hypertension, heart failure, endothelial dysfunction, and metabolic syndrome. The pathophysiology of cardiac syndrome X (CSX) involves many pathways that are influenced by vitamin D levels. This study aimed to investigate the relationship between vitamin D deficiency and abnormal blood pressure response to exercise in patients with CSX. Methods: This was a cross-sectional and observational study. Fifty females with normal epicardial coronary arteries who presented with typical symptoms of rest or effort angina and 41 healthy age-matched female controls, were included. Patients with cardiomyopathy, severe valvular disease, congenital heart disease, and left ventricular hypertrophy were excluded. All patients underwent stress electrocardiography examination and 25-hydroxy (OH) vitamin D level measurements. Results: Levels of 25-OH vitamin D were significantly lower in CSX patients (9.8±7.3 ng/mL vs. 18.1±7.9 ng/mL; p<0.001). Systolic blood pressure (SBP) (188±15 mm Hg vs. 179±17 mm Hg; p=0.013) and diastolic blood pressure (DBP) (98±9 mm Hg vs. 88±9 mm Hg; p<0.001) during peak exercise were higher in CSX patients. Levels of 25-OH vitamin D were negatively correlated with peak SBP (r=–0.310, p=0.004) and peak DBP (r=–0.535, p<0.001) during exercise. To discard the multicollinearity problem, two different models were used for multivariate analyses. In the first model, metabolic equivalents (METs) (p=0.003) and 25-OH vitamin D levels (p=0.001) were independent predictors. METs (p=0.007), 25-OH vitamin D levels (p=0.008), and peak DBP were determined as independent predictors in the second multivariate model. Conclusion: In patients with CSX, 25-OH vitamin D levels were lower than those in controls; moreover, 25-OH vitamin D deficiency was also associated with higher levels of peak DBP during exercise. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Turkish Society of Cardiology | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | 25-OH Vitamin D | en_US |
dc.subject | Abnormal Blood Pressure Response | en_US |
dc.subject | Cardiac Syndrome X | en_US |
dc.title | Assessment of 25-OH vitamin D levels and abnormal blood pressure response in female patients with cardiac syndrome X | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Anatolian Journal of Cardiology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-4607-5724 | en_US |
dc.authorid | 0000-0001-9975-5507 | en_US |
dc.identifier.volume | 16 | en_US |
dc.identifier.issue | 12 | en_US |
dc.identifier.startpage | 961 | en_US |
dc.identifier.endpage | 966 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.14744/AnatolJCardiol.2016.6862 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.scopusquality | Q3 | en_US |