dc.contributor.author | Ötünçtemur, Alper | |
dc.contributor.author | Özbek, Emin | |
dc.contributor.author | Şahin, Süleyman | |
dc.contributor.author | Özcan, Levent | |
dc.contributor.author | Dursun, Murat | |
dc.contributor.author | Polat, Emre Can | |
dc.contributor.author | Çekmen, Mustafa Baki | |
dc.contributor.author | Özsoy, Özgür Doğa | |
dc.contributor.author | Erkoç, Mustafa | |
dc.contributor.author | Daniş, Eyüp | |
dc.contributor.author | Bozkurt, Muammer | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:36:56Z | |
dc.date.available | 10.07.201910:49:14 | |
dc.date.available | 2019-07-10T19:36:56Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Ötünçtemur A., Özbek E., Şahin S., Özcan L., Dursun M., Polat E. C. ... Bozkurt M. (2016). Low serum insulin-like growth factor-1 in patients with erectile dysfunction. Basic and Clinical Andrology, 26. https://dx.doi.org/10.1186/s12610-015-0028-x | en_US |
dc.identifier.issn | 2051-4190 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/1291 | |
dc.identifier.uri | https://dx.doi.org/10.1186/s12610-015-0028-x | |
dc.description.abstract | Objective: Endothelial dysfunction and microvascular damage play a crurical role in the pathogenesis of erectile dysfunction (ED). Insulin-like growth factor-1 (IGF-1) is one of the growth factors that have a wide range of biologic effects. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues. The purpose of the current study was to determine the association between IGF-1 levels and ED. Materials and methods: All men were evaluated for ED and divided into two groups: 80 patients suffering from ED for > 1 year and 80 subjects without ED were enrolled as a control group in this study. Diagnosis of ED was based on the International Index of Erectile Function Score-5. IGF-1 levels were measured in serum by an automated chemiluminescence immunoassay. The relationship between IGF-1 levels and ED scores in patients was statistically evaluated. Results: The mean age of patients in ED group was 60.4 ± 11.3 years and 55.4 ± 9.6 in control group. The plasma IGF-1 levels were significantly lower in ED than in control group (96.5 ± 38.3 and 132.5 ± 53.3 ng/ mL, respectively, P < 0.001). The IGF-1 levels were positively correlated with ED score (r = 0.623, P < 0.01). Conclusion: In this study serum IGF-1 levels were found to be associated with endothelial dysfunction that predicts ED. Serum IGF-1 level appears to be a specific predictor of ED, and it might be used in early prediction of ED in male population. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | BioMed Central Ltd. | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Endothelial Dysfunction | en_US |
dc.subject | Erectile Dysfunction | en_US |
dc.subject | Insulin-Like Growth Factor-1 | en_US |
dc.subject | International Index of Erectile Function Score-5 | en_US |
dc.title | Low serum insulin-like growth factor-1 in patients with erectile dysfunction | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Basic and Clinical Andrology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0001-5254-2563 | en_US |
dc.identifier.volume | 26 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1186/s12610-015-0028-x | en_US |
dc.identifier.scopusquality | Q2 | en_US |