Effects of melatonin and 5-methoxytryptophol on synovial inflammation in the zymosan-induced rheumatoid arthritis in rats
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2016Author
Savtekin, GökçeTuzum, Mustafa Şenol
Uyanık, Lokman Onur
Ayalı, Ayşa
Öğünç Velioğlu, Ayliz
Çetinel, Şule
Kılıç, Ertuğrul
Şehirli, Ahmet Özer
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Savtekin, G., Tuzum, M. Ş., Uyanık, L. O., Ayalı, A., Öğünç Velioğlu, A., Çetinel, Ş. ... Şehirli, A. Ö. (2016). Effects of melatonin and 5-methoxytryptophol on synovial inflammation in the zymosan-induced rheumatoid arthritis in rats. International Journal of Clinical and Experimental Medicine, 9(4), 7137-7144.Abstract
The aim of this study is the investigation of synoviocytes, cytokines and metalloproteinases in the synovial inflammation model which is created by zymosan application to temporomandibular joint (TMJ) and effects of pineal hormones melatonin (MEL) and 5-methoxytryptophol (5-MTX) on these parameters. 200-250 g Wistar albino rats of both sexes were used for modeling arthritis in this study. Arthritis model was created by intraarticularly (i.a.) injecting 2 mg zymosan in 40 ml saline into the left temporamandibular joint of the rats while the sham group was created by only injecting 40 ml saline solution (intraarticulary). MEL and 5-MTX administration was made intraperitoneal before zymosan injection. 6 hours after zymosan or saline administration of MEL and 5-MTX the synovial fluid was collected from the animals and the synovial membrane was collected for histological assessment. The administration of zymosan increased the release of IL-1ß and TNF? and the activity of metalloproteinases (MMM-9) and metalloproteinases-2 (MMP-2) and with this administration values got closer to the sham group. The histological evaluation showed significant increase in the intensity of synoviocytes that arose in the inflammation was found to subside. In conclusion, MEL and 5-MTX reducing inflammation in arthritis suggests these agents might constitute a new therapeutic principle clinically.
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International Journal of Clinical and Experimental MedicineVolume
9Issue
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