The status of spermatogenesis in germ cell tumor bearing testis and its association with metastatic disease
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2024Author
Çulpan, MeftunYıldırım, Asıf
Özkanlı, Sıdıka Şeyma
Sobay, Resul
Gürsoy, Fatıma
Topaktaş, Ramazan
Gümrükçü, Gülistan
Görgel, Sacit Nuri
Çakalağaoğlu, Fulya
Çil, Gökhan
Özsoy, Şule
Günel, Hümeyra
Küçük, Eyüp Veli
Öztürk, Metin İshak
Akın, Yiğit
Müslümanoğlu, Ahmet Yaser
Aydın, Abdullah
del Pilar Laguna Pes, Maria
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Çulpan, M., Yıldırım, A., Özkanlı, S. Ş., Sobay, R., Gürsoy, F., Topaktaş, R. ... del Pilar Laguna Pes, M. (2024). The status of spermatogenesis in germ cell tumor bearing testis and its association with metastatic disease. Clinical Genitourinary Cancer, 22(3). http://dx.doi.org/10.1016/j.clgc.2024.102089Abstract
Introduction: We aimed to evaluate the status of spermatogenesis detected by histological examination of non-tumoral testicular tissues in tumor bearing testis and its association with advanced stage disease. Patients and Methods: We retrospectively reviewed patients with testicular germ cell tumors (TGCTs) that undergone radical orchiectomy. All non-tumoral areas of the orchiectomy specimens were examined for the status of spermatogenesis. Patients were divided into two groups as localized (stage I) and metastatic (stage II-III) disease and analyzed separately for seminomatous (SGCT) and nonseminomatous germ cell tumors (NSGCT). Results: Four hundred fifty-four patients were included in our final analysis. Of those, 195 patients had SGCT, and 259 patients had NSGCT. Three hundred and six patients had localized disease at the time of diagnosis. Median (Q1-Q3) age was 31 (26 – 38) years and 102 (22.5%) patients had normal spermatogenesis, 177 (39.0%) patients had hypospermatogenesis and 175 (38.5%) patients had no mature spermatozoa. On multivariate logistic regression analysis, embryonal carcinoma >50% (1.944, 95 %CI 1.054-3.585, P = .033) and spermatogenesis status (2.796 95% CI 1.251-6.250, P = .012 for hypospermatogenesis, and 3.907, 95% CI 1.692-9.021, P = .001 for absence of mature spermatozoa) were independently associated with metastatic NSGCT. However, there was not any variables significantly associated with metastatic SGCT on multivariate logistic regression analysis. Conclusion: Our study demonstrated that only 22.5% of patients with TGCTs had normal spermatogenesis in tumor bearing testis. Impaired spermatogenesis (hypospermatogenesis or no mature spermatozoa) and predominant embryonal carcinoma are associated with advanced stage NSGCT.
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Clinical Genitourinary CancerVolume
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