Resting state electroencephalographic alpha rhythms are sensitive to Alzheimer's disease mild cognitive impairment progression at a 6-month follow-up
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info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivs 4.0 Internationalhttps://creativecommons.org/licenses/by-nc-nd/4.0/Date
2024Author
Babiloni, ClaudioJakhar, Dharmendra
Tucci, Federico
Del Percio, Claudio
Lopez, Susanna
Soricelli, Andrea
Salvatore, Marco
Ferri, Raffaele
Catania, Valentina
Massa, Federico
Arnaldi, Dario
Famà, Francesco
Güntekin, Bahar
Yener, Görsev
Stocchi, Fabrizio
Vacca, Laura
Marizzoni, Moira
Giubilei, Franco
Yıldırım, Ebru
Hanoğlu, Lütfü
Hünerli, Duygu
Frisoni, Giovanni B.
Noce, Giuseppe
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Babiloni, C., Jakhar, D., Tucci, F., Del Percio, C., Lopez, S., Soricelli, A. ... Noce, G. (2024). Resting state electroencephalographic alpha rhythms are sensitive to Alzheimer's disease mild cognitive impairment progression at a 6-month follow-up. Neurobiology of Aging, 137, 19-37. http://dx.doi.org/10.1016/j.neurobiolaging.2024.01.013Abstract
Are posterior resting-state electroencephalographic (rsEEG) alpha rhythms sensitive to the Alzheimer's disease mild cognitive impairment (ADMCI) progression at a 6-month follow-up? Clinical, cerebrospinal, neuroimaging, and rsEEG datasets in 52 ADMCI and 60 Healthy old seniors (equivalent groups for demographic features) were available from an international archive (www.pdwaves.eu). The ADMCI patients were arbitrarily divided into two groups: REACTIVE and UNREACTIVE, based on the reduction (reactivity) in the posterior rsEEG alpha eLORETA source activities from the eyes-closed to eyes-open condition at ≥ −10% and −10%, respectively. 75% of the ADMCI patients were REACTIVE. Compared to the UNREACTIVE group, the REACTIVE group showed (1) less abnormal posterior rsEEG source activity during the eyes-closed condition and (2) a decrease in that activity at the 6-month follow-up. These effects could not be explained by neuroimaging and neuropsychological biomarkers of AD. Such a biomarker might reflect abnormalities in cortical arousal in quiet wakefulness to be used for clinical studies in ADMCI patients using 6-month follow-ups.
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Neurobiology of AgingVolume
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http://dx.doi.org/10.1016/j.neurobiolaging.2024.01.013https://hdl.handle.net/20.500.12511/12488
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