Genetic testing and counseling challenges in personalized breast cancer care: review article with insights from Türkiye
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Erişim
info:eu-repo/semantics/openAccessTarih
2024Yazar
Çiçin, İrfanKaradurmuş, Nuri
Bilici, Ahmet
Bahsi, Taha
Şendur, Mehmet Ali
Demirci, Umut
Göksu, Sema Sezgin
Er, Özlem
Bişgin, Atıl
Öztürk Sağlam, Özge Fulya
Aver, Birkan
Kılıçkap, Saadettin
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Çiçin, İ., Karadurmuş, N., Bilici, A., Bahsi, T., Şendur, M. A., Demirci, U. ... Kılıçkap, S. (2024). Genetic testing and counseling challenges in personalized breast cancer care: review article with insights from Türkiye. Future Oncology, 20(15). http://dx.doi.org/10.2217/fon-2023-0518Özet
According to current evidence, testing for germline BRCA pathogenic variants in newly diagnosed breast cancer (BC) patients has the potential to reduce the burden of the disease through targeted therapies and secondary prevention. A personalized approach to testing can lead to improved individual outcomes for patients. Despite the proven clinical utility and therapeutic impact of BRCA1/2 tests in shaping therapy for metastatic BC, awareness and access to these tests are limited in many developing countries, including Turkiye. This limitation impacts the healthcare economy as delayed or missed interventions can lead to increased long-term costs. The limited access is mainly due to fear of stigmatization among patients, country-specific legislation and costs, a lack of awareness, vagueness surrounding the tests and access restrictions. This review offers a perspective for policymakers and healthcare providers in Turkiye to establish pathways that integrate the patient experience into comprehensive care pathways and national cancer control plans.