Preoperative co-application of bevacizumab and tissue plasminogen activator in vitrectomy for proliferative diabetic retinopathy
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2024Author
Aras, CengizŞentürk, Fevzi
Karaman Erdur, Sevil
Kocabora, Mehmet Selim
Doğramacı, Mahmut
Burke, Cahit
Aras, Efe
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Aras, C., Şentürk, F., Karaman Erdur, S., Kocabora, M. S., Doğramacı, M., Burke, C. ... Aras, E. (2024). Preoperative co-application of bevacizumab and tissue plasminogen activator in vitrectomy for proliferative diabetic retinopathy. Arquivos Brasileiros de Oftalmologia, 87(2). https://dx.doi.org/10.5935/0004-2749.2023-0001Abstract
PURPOSE: To investigate the clinical benefits of the co-application of bevacizumab and tissue plasminogen activator as adjuncts in the surgical treatment of proliferative diabetic retinopathy.
METHODS: Patients who underwent vitrectomy for proliferative diabetic retinopathy complications were preoperatively given intravitreal injection with either bevacizumab and tissue plasminogen activator (Group 1) or bevacizumab alone (Group 2). Primary outcomes were surgery time and number of intraoperative iatrogenic retinal breaks. Secondary outcomes included changes in the best-corrected visual acuity and postoperative complications at 3 months postoperatively.
RESULTS: The mean surgery time in Group 1 (52.95 +/- 5.90 min) was significantly shorter than that in Group 2 (79.61 +/- 12.63 min) (p<0.001). The mean number of iatrogenic retinal breaks was 0.50 +/- 0.59 (0-2) in Group 1 and 2.00 +/- 0.83 (0-3) in Group 2 (p<0.001). The best-corrected visual acuity significantly improved in both groups (p<0.001). One eye in each group developed retinal detachment.
CONCLUSION: Preoperative co-application of bevacizumab and tissue plasminogen activator as adjuncts in the surgical treatment of proliferative diabetic retinopathy shortens the surgery time and reduces the number of intraoperative iatrogenic retinal breaks.
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Arquivos Brasileiros de OftalmologiaVolume
87Issue
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