dc.contributor.author | Altuntaş, Şükriye Leyla | |
dc.contributor.author | Güneş, Arzu | |
dc.contributor.author | Kaplan, Arife Ahsen | |
dc.contributor.author | Ayşit, Neşe | |
dc.contributor.author | Keskin, İlknur | |
dc.date.accessioned | 2024-02-16T08:01:05Z | |
dc.date.available | 2024-02-16T08:01:05Z | |
dc.date.issued | 2024 | en_US |
dc.identifier.citation | Altuntaş, Ş. L., Güneş, A., Kaplan, A. A., Ayşit, N. ve Keskin, İ. (2024). Unravelling the impact of COVID-19 on pregnancy: In aspect of placental histopathology and umbilical cord macrophage immunoactivity with neonatal outcomes. Journal of Reproductive Immunology, 162. https://dx.doi.org/10.1016/j.jri.2024.104207 | en_US |
dc.identifier.issn | 0165-0378 | |
dc.identifier.issn | 1872-7603 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.jri.2024.104207 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/12284 | |
dc.description.abstract | COVID-19 has turned into a global pandemic since it was first detected in 2019, causing serious public health problems. Our objective was to investigate the impact of COVID-19 on pregnant women and newborns, who belong to the vulnerable segments of society. Our study involved the histopathological examination of placentas and umbilical cords from two groups of pregnant women. Group I consisted of pregnant women who had never tested positive for COVID-19 during their pregnancy (n: 20). Group II consisted of pregnant women who had contracted COVID-19, exhibited moderate and mild symptoms, and recovered from the disease before giving birth (n: 23). Furthermore, we employed immunofluorescence techniques to detect macrophage activity in the umbilical cord. Prenatal assessments were based on maternal complete blood counts and coagulation assays (n:40 in both groups). Newborn conditions were evaluated using birth weight, height, head circumference, and APGAR (n:40 in both groups). Our analyses reveal that COVID-19 causes placental and umbilical cord inflammation and maternal and foetal vascular malperfussion. Our immunofluorescence investigations demonstrate a notable increase in macrophage numbers and the macrophage-to-total cell ratio within the COVID-19 group. In this aspect, this study provides the initial report incorporating macrophage activity results from Warton's jelly in pregnants who have recovered from COVID-19. We have also ascertained that COVID-19 abbreviates gestation periods and concurrently diminishes maternal haemoglobin concentrations. Consequently, COVID-19 with mild and moderate symptoms during pregnancy, causes significant changes to the placenta and umbilical cord, but propitiously does not cause a significant difference in the neonatal outcomes. | en_US |
dc.description.sponsorship | Health Science and Technologies Research Institute ; Koşuyolu Medipol Hospital ; SABITA ; Istanbul Medipol University | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Ireland Ltd | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Immunofluorescence | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Macrophage | en_US |
dc.subject | Placenta | en_US |
dc.subject | Umbilical Cord | en_US |
dc.title | Unravelling the impact of COVID-19 on pregnancy: In aspect of placental histopathology and umbilical cord macrophage immunoactivity with neonatal outcomes | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Reproductive Immunology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Histoloji ve Embriyoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-1985-552X | en_US |
dc.authorid | 0000-0003-2496-7673 | en_US |
dc.authorid | 0000-0002-6984-3079 | en_US |
dc.authorid | 0000-0002-4243-9092 | en_US |
dc.identifier.volume | 162 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.jri.2024.104207 | en_US |
dc.institutionauthor | Altuntaş, Şükriye Leyla | |
dc.institutionauthor | Güneş, Arzu | |
dc.institutionauthor | Kaplan, Arife Ahsen | |
dc.institutionauthor | Ayşit, Neşe | |
dc.institutionauthor | Keskin, İlknur | |
dc.identifier.scopus | 2-s2.0-85184023914 | en_US |
dc.identifier.pmid | 38301595 | en_US |
dc.identifier.scopusquality | Q2 | en_US |