Poor reactivity of posterior electroencephalographic alpha rhythms during the eyes open condition in patients with dementia due to Parkinson's disease
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Erişim
info:eu-repo/semantics/openAccessTarih
2024Yazar
Babiloni, ClaudioNoce, Giuseppe
Tucci, Federico
Jakhar, Dharmendra
Ferri, Raffaele
Panerai, Simonetta
Catania, Valentina
Soricelli, Andrea
del Percio, Claudio
Üst veri
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Babiloni, C., Noce, G., Tucci, F., Jakhar, D., Ferri, R., Panerai, S. ... del Percio, C. (2024). Poor reactivity of posterior electroencephalographic alpha rhythms during the eyes open condition in patients with dementia due to Parkinson's disease. Neurobiology of Aging, 135, 1-14. https://dx.doi.org/10.1016/j.neurobiolaging.2023.11.010Özet
Here, we hypothesized that the reactivity of posterior resting-state electroencephalographic (rsEEG) alpha rhythms during the transition from eyes-closed to -open condition might be lower in patients with Parkinson's disease dementia (PDD) than in patients with Alzheimer's disease dementia (ADD). A Eurasian database provided clinical-demographic-rsEEG datasets in 73 PDD patients, 35 ADD patients, and 25 matched cognitively unimpaired (Healthy) persons. The eLORETA freeware was used to estimate cortical rsEEG sources. Results showed substantial (greater than −10%) reduction (reactivity) in the posterior alpha source activities from the eyes-closed to the eyes-open condition in 88% of the Healthy seniors, 57% of the ADD patients, and only 35% of the PDD patients. In these alpha-reactive participants, there was lower reactivity in the parietal alpha source activities in the PDD group than in the healthy control seniors and the ADD patients. These results suggest that PDD patients show poor reactivity of mechanisms desynchronizing posterior rsEEG alpha rhythms in response to visual inputs. That neurophysiological biomarker may provide an endpoint for (non) pharmacological interventions for improving vigilance regulation in those patients.
Scopus Q Kategorisi
Q1Kaynak
Neurobiology of AgingCilt
135Bağlantı
https://dx.doi.org/10.1016/j.neurobiolaging.2023.11.010https://hdl.handle.net/20.500.12511/12093
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