dc.contributor.author | Karakurt, Gökhan | |
dc.contributor.author | Üçgün, Hikmet | |
dc.contributor.author | Aynacı, Engin | |
dc.contributor.author | Düger, Mustafa | |
dc.contributor.author | Demir, Şükrü Egemen | |
dc.date.accessioned | 2023-12-25T12:53:55Z | |
dc.date.available | 2023-12-25T12:53:55Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Karakurt, G., Üçgün, H., Aynacı, E., Düger, M. ve Demir, Ş. E. (2023). Long-term efficacy of different doses of steroid in hospitalized COVID-19 patients: A prospective cohort study. Pneumon, 36(4). https://dx.doi.org/10.18332/pne/174604 | en_US |
dc.identifier.issn | 1105-848X | |
dc.identifier.issn | 1791-4914 | |
dc.identifier.uri | https://dx.doi.org/10.18332/pne/174604 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/12070 | |
dc.description.abstract | INTRODUCTION The aim of our study was to investigate the long-term effects of different doses of steroid therapy given in the acute period in hospitalized coronavirus disease 2019 (COVID-19) patients. METHODS A total of 78 patients who were followed up in the hospital due to COVID-19 pneumonia and were discharged from the hospital more than 3 months ago, were included in our study. The patients were divided into 3 groups according to the steroid doses they received. RESULTS The value of peak expiratory flow (PEF) was significantly lower in pulse-dose steroid group compared to high-dose steroid group (p=0.040). There was a significant difference in the values of carbon monoxide diffusion capacity (DLCO) and diffusion coefficient of alveolar volume (DLCO/VA) among all groups (p=0.027, p=0.048). The values of DLCO and DLCO/VA were significantly lower in the pulse-dose steroid group compared to the high-dose steroid group (p=0.022, p=0.049). The computed tomography (CT) score was significantly higher in the pulse-dose steroid group compared to both the nonsteroid group and high-dose steroid group (p=0.027, p=0.043). CONCLUSIONS Pulse-dose steroid therapy given in the acute period of COVID-19 pneumonia may negatively affect pulmonary function and recovery in the long-term. In addition, high-dose steroids were found to have a positive effect on pulmonary function compared to pulse-steroid therapy and nonsteroid therapy. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | European Publishing | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution-NonCommercial 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | COVID-19 | en_US |
dc.subject | DLCO | en_US |
dc.subject | Pulmonary Function | en_US |
dc.subject | Steroid | en_US |
dc.title | Long-term efficacy of different doses of steroid in hospitalized COVID-19 patients: A prospective cohort study | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Pneumon | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-4091-6465 | en_US |
dc.identifier.volume | 36 | en_US |
dc.identifier.issue | 4 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.18332/pne/174604 | en_US |
dc.institutionauthor | Düger, Mustafa | |
dc.identifier.wos | 001118606300001 | en_US |
dc.identifier.scopus | 2-s2.0-85179328818 | en_US |
dc.identifier.scopusquality | Q4 | en_US |