dc.contributor.author | Cannarella, Rossella | |
dc.contributor.author | Shah, Rupin | |
dc.contributor.author | Abo-Almagd Abdel-Meguid Hamoda, Taha | |
dc.contributor.author | Boitrelle, Florence | |
dc.contributor.author | Saleh, Ramadan | |
dc.contributor.author | Gül, Murat | |
dc.contributor.author | Rambhatla, Amarnath | |
dc.contributor.author | Kavoussi, Parviz | |
dc.contributor.author | Sofikitis, Nikolaos | |
dc.date.accessioned | 2023-11-17T11:36:13Z | |
dc.date.available | 2023-11-17T11:36:13Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Cannarella, R., Shah, R., Abo-Almagd Abdel-Meguid Hamoda, T., Boitrelle, F., Saleh, R., Gül, M. ... Sofikitis, N. (2023). Does varicocele repair improve conventional semen parameters? A meta-analytic study of before-after data. World Journal of Men's Health, 41. https://dx.doi.org/10.5534/wjmh.230034 | en_US |
dc.identifier.issn | 2287-4208 | |
dc.identifier.issn | 2287-4690 | |
dc.identifier.uri | https://dx.doi.org/10.5534/wjmh.230034 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/11799 | |
dc.description.abstract | Purpose: The purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-person conventional semen parameters before and after the repair of varicoceles. Materials and Methods: The meta-analysis was performed according to PRISMA-P and MOOSE guidelines. A systematic search was performed in Scopus, PubMed, Cochrane, and Embase databases. Eligible studies were selected according to the PICOS model (Population: infertile male patients with clinical varicocele; Intervention: varicocele repair; Comparison: intra-person before-after varicocele repair; Outcome: conventional semen parameters; Study type: randomized controlled trials [RCTs], observational and case-control studies). Results: Out of 1,632 screened abstracts, 351 articles (23 RCTs, 292 observational, and 36 case-control studies) were included in the quantitative analysis. The before-and-after analysis showed significant improvements in all semen parameters after varicocele repair (except sperm vitality); semen volume: standardized mean difference (SMD) 0.203, 95% CI: 0.129–0.278; p<0.001; I2=83.62%, Egger’s p=0.3329; sperm concentration: SMD 1.590, 95% CI: 1.474–1.706; p<0.001; I2=97.86%, Egger’s p<0.0001; total sperm count: SMD 1.824, 95% CI: 1.526–2.121; p<0.001; I2=97.88%, Egger’s p=0.0063; total motile sperm count: SMD 1.643, 95% CI: 1.318–1.968; p<0.001; I2=98.65%, Egger’s p=0.0003; progressive sperm motility: SMD 1.845, 95% CI: 1.537%–2.153%; p<0.001; I2=98.97%, Egger’s p<0.0001; total sperm motility: SMD 1.613, 95% CI 1.467%–1.759%; p<0.001; l2=97.98%, Egger’s p<0.001; sperm morphology: SMD 1.066, 95% CI 0.992%–1.211%; p[removed]. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Korean Society for Sexual Medicine and Andrology | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Controlled Before-After Studies | en_US |
dc.subject | Infertility | en_US |
dc.subject | Male | en_US |
dc.subject | Meta-Analysis | en_US |
dc.subject | Varicocele | en_US |
dc.title | Does varicocele repair improve conventional semen parameters? A meta-analytic study of before-after data | en_US |
dc.type | article | en_US |
dc.relation.ispartof | World Journal of Men's Health | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-6308-1763 | en_US |
dc.identifier.volume | 41 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.5534/wjmh.230034 | en_US |
dc.institutionauthor | de la Rosette, Jean J. M. C. H. | |
dc.identifier.scopus | 2-s2.0-85175731583 | en_US |
dc.identifier.pmid | 37382284 | en_US |
dc.identifier.scopusquality | Q1 | en_US |