dc.contributor.author | Gökçe, Mustafa | |
dc.contributor.author | Velioğlu, Halil Aziz | |
dc.contributor.author | Bektay, Muhammed Yunus | |
dc.contributor.author | Güler, Eray Metin | |
dc.date.accessioned | 2023-10-26T06:59:06Z | |
dc.date.available | 2023-10-26T06:59:06Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Gökçe, M., Velioğlu, H. A., Bektay, M. Y. ve Güler, E. M. (2023). Evaluating the clinical significance of diazepam binding inhibitor in alzheimer's disease: A comparison with inflammatory, oxidative, and neurodegenerative biomarkers. Gerontology, 69(9), 1104-1112. https://dx.doi.org/10.1159/000531849 | en_US |
dc.identifier.issn | 0304-324X | |
dc.identifier.issn | 1423-0003 | |
dc.identifier.uri | https://dx.doi.org/10.1159/000531849 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/11643 | |
dc.description.abstract | Introduction: Alzheimer's disease (AD) is one of the pathologies that the scientific world is still desperate for. The aim of this study was the investigation of diazepam binding inhibitor (DBI) as a prognostic factor for AD prognosis. Methods: A total of 120 participants were divided into 3 groups. Forty new diagnosed Alzheimer patients (NDG) who have been diagnosed but have not started AD treatment, 40 patients who diagnosed 5 years ago (D5YG), and 40 healthy control groups (CG) were included in the study. Levels of DBI, oxidative stress, inflammatory, and neurodegenerative biomarkers were compared between 3 groups. Results: Plasma levels of DBI, oligomeric Aβ, total tau, glial fibrillary acidic protein, α-synuclein, interleukin (IL) 1β, IL6, tumor necrosis factor α, oxidative stress index, high-sensitive C-reactive protein, and DNA damage were found higher in D5YG and NDG as compared to CG (p < 0.001). On the contrary, plasma levels of total thiol, native thiol, vitamin D and vitamin B12 were lower in D5YG and NDG as compared to CG (p < 0.001). Discussion: DBI may be a potential plasma biomarker and promising drug target for AD. It could help physicians make a comprehensive evaluation with cognitive and neurodegenerative tests. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Karger | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution-NonCommercial 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/deed.en | * |
dc.subject | Diazepam Binding Inhibitor | en_US |
dc.subject | Alzheimer’s Disease | en_US |
dc.subject | Ageing | en_US |
dc.subject | Biomarker | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Oxidative Stress | en_US |
dc.title | Evaluating the clinical significance of diazepam binding inhibitor in alzheimer's disease: A comparison with inflammatory, oxidative, and neurodegenerative biomarkers | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Gerontology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü | en_US |
dc.authorid | 0000-0002-2306-5937 | en_US |
dc.identifier.volume | 69 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.startpage | 1104 | en_US |
dc.identifier.endpage | 1112 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1159/000531849 | en_US |
dc.institutionauthor | Velioğlu, Halil Aziz | |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.wos | 001067761300006 | en_US |
dc.identifier.scopus | 2-s2.0-85170555128 | en_US |
dc.identifier.pmid | 37607528 | en_US |
dc.identifier.scopusquality | Q1 | en_US |