A successful treatment approach in 2 patients with type 1 plasminogen deficiency: Intratracheal application of fresh frozen plasma and tissue plasminogen activator
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info:eu-repo/semantics/embargoedAccessTarih
2023Yazar
Al, SerdarUlusoy, Oktay
Asilsoy, Suna
Uzuner, Nevin
Kangallı, Özge
Atay, Özge
Odaman Al, Işık
Ateş, Oğuz
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Al, S., Ulusoy, O., Asilsoy, S., Uzuner, N., Kangallı, Ö., Atay, Ö. ... Ateş, O. (2023). A successful treatment approach in 2 patients with type 1 plasminogen deficiency: Intratracheal application of fresh frozen plasma and tissue plasminogen activator. Journal of Pediatric Hematology/Oncology, 45(7), 423-426. https://doi.org/10.1097/MPH.0000000000002698Özet
BACKGROUND: Respiratory system involvement is common in congenital plasminogen deficiency. Although many treatment approaches have been tried, there is still no definitive treatment for respiratory system involvement. OBSERVATIONS: We report 2 congenital plasminogen deficiency cases, who presented with severe respiratory symptoms, for whom a novel treatment modality was tried. After intravenous administration of FFP (fresh frozen plasma), tissue plasminogen activator and FFP were administered intratracheally, and respiratory system findings improved. CONCLUSIONS: Intratracheal administration of tissue plasminogen activator and FFP is an available treatment modality for patients with lung involvement. Fibrin plaques should be carefully removed and new lesion formation should be prevented.
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Journal of Pediatric Hematology/OncologyCilt
45Sayı
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