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In vitro cytotoxicity evaluation and phytochemical analysis of Ajuga reptans L. extracts

dc.contributor.authorÇaşkurlu, Ayşegül
dc.contributor.authorKaravuş, Şule Nur
dc.contributor.authorBiltekin, Sevde Nur
dc.contributor.authorHelvacı, Esra Zeynep
dc.contributor.authorKaradağ, Ayşe Esra
dc.date.accessioned2023-10-02T09:05:07Z
dc.date.available2023-10-02T09:05:07Z
dc.date.issued2023en_US
dc.identifier.citationÇaşkurlu, A., Karavuş, Ş. N., Biltekin, S. N., Helvacı, E. Z. ve Karadağ, A. E. (2023). In vitro cytotoxicity evaluation and phytochemical analysis of Ajuga reptans L. extracts. Journal of Research in Pharmacy, 27(5), 2115-2123. https://doi.org/10.29228/jrp.2022.00en_US
dc.identifier.issn2630-6344
dc.identifier.urihttps://doi.org/10.29228/jrp.2022.00
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11511
dc.description.abstractThe aim of this study was to evaluate phytochemical composition of Ajuga reptans L. (Lamiaceae) aerial parts (separately flower and leaf) methanol, aqueous-methanolic extracts, and their cytotoxic activities. The phytochemical analysis was performed high-performance liquid chromatography (HPLC). Caffeic acid, p-coumaric, gallic, chlorogenic, ferulic acids, kaempferol, rutin, quercetin, quercetin-3-O-galactoside, and quercitrin were used as reference substances by HPLC in all samples. The major compounds in the extract were found as ferulic acid, caffeic acid, rutin, and quercetin-3-O-galactoside. Cytotoxicity was investigated using methyl thiazole tetrazolium (MTT) assay. Cytotoxic evaluation of the extracts against cancer (MCF7, PC3, and A549) and healthy human embryonic kidney cell line (HEK293) cell lines by MTT. Compared to other cells, the methanol extract of A. reptans demonstrated high selectivity against PC3 cells (IC50: 95 ± 0.99 µg/mL) and selectivity index was four times higher than reference drug colchicine. (IC50: 95 ± 0.99 µg/mL, SI: 6.10). A. reptans demonstrated antiproliferative potential against prostate and lung cancer cells. Therefore, additional investigations are needed to study the mechanism of the cytotoxicity for A. reptans.en_US
dc.language.isoengen_US
dc.publisherMarmara Universityen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAjugaen_US
dc.subjectCytotoxicityen_US
dc.subjectHPLCen_US
dc.subjectLamiaceaeen_US
dc.titleIn vitro cytotoxicity evaluation and phytochemical analysis of Ajuga reptans L. extractsen_US
dc.typearticleen_US
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalıen_US
dc.authorid0000-0001-7277-920Xen_US
dc.authorid0000-0001-9265-8042en_US
dc.authorid0000-0003-1896-2729en_US
dc.authorid0000-0002-3412-0807en_US
dc.identifier.volume27en_US
dc.identifier.issue5en_US
dc.identifier.startpage2115en_US
dc.identifier.endpage2123en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.29228/jrp.2022.00en_US
dc.institutionauthorÇaşkurlu, Ayşegül
dc.institutionauthorKaravuş, Şule Nur
dc.institutionauthorBiltekin, Sevde Nur
dc.institutionauthorHelvacı, Esra Zeynep
dc.institutionauthorKaradağ, Ayşe Esra
dc.identifier.scopus2-s2.0-85171836463en_US
dc.identifier.scopusqualityQ3en_US


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