dc.contributor.author | Yay, Ekin | |
dc.contributor.author | Yılmaz, Melis | |
dc.contributor.author | Toygar, Hilal | |
dc.contributor.author | Balcı, Nur | |
dc.contributor.author | Alvarez Rivas, Carla | |
dc.contributor.author | Bolluk Kılıç, Başak | |
dc.contributor.author | Zırh, Ali | |
dc.contributor.author | Paster, Bruce | |
dc.contributor.author | Kantarcı, Alpdoğan | |
dc.date.accessioned | 2023-09-12T10:44:11Z | |
dc.date.available | 2023-09-12T10:44:11Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Yay, E., Yılmaz, M., Toygar, H., Balcı, N., Alvarez Rivas, C., Bolluk Kılıç, B. ... Kantarcı, A. (2023). Parkinson’s disease alters the composition of subgingival microbiome. Journal of Oral Microbiology, 15(1). https://dx.doi.org/10.1080/20002297.2023.2250650 | en_US |
dc.identifier.issn | 2000-2297 | |
dc.identifier.uri | https://dx.doi.org/10.1080/20002297.2023.2250650 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/11414 | |
dc.description.abstract | Aim: The current study aimed to test the hypothesis that Parkinson’s disease exacerbates periodontitis by altering its microbiome. Materials and Methods: Clinical periodontal parameters were recorded. Subgingival samples from healthy controls, periodontitis patients (PD), and Parkinson’s patients with periodontitis (PA+PD) were analyzed using the checkerboard DNA-DNA hybridization technique for targeting 40 bacterial species typically associated with periodontal disease and health. Next-generation sequencing (NGS) of the 16S ribosomal RNA gene (V1-V3 regions) was performed to analyze the microbiome comprehensively. Results: Parkinson’s patients had mild-to-moderate motor dysfunctions. Bleeding on probing was significantly increased in the PA+PD group compared to PD (p < 0.05). With checkerboard analysis, PA was associated with increased Treponema socranskii (p = 0.0062), Peptostreptococcaceae_[G-6] [Eubacterium]_nodatum (p = 0.0439), Parvimona micra (p < 0.0001), Prevotella melaninogenica (p = 0.0002), Lachnoanaerobaculum saburreum (p < 0.0001), and Streptococcus anginosus (p = 0.0020). Streptococcus intermedia (p = 0.0042), P.nodatum (p = 0.0022), P.micra (p = 0.0002), Treponema denticola (p = 0.0045), L.saburreum (p = 0.0267), P.melaninogenica (p = 0.0017), Campylobacter rectus (p = 0.0020), and T.socranskii (p = 0.0002) were higher; Aggregatibacter actinomycetemcomitans (p = 0.0072) was lower in deep pockets in the PA+PD compared to PD. Schaalia odontolytica (p = 0.0351) and A.actinomycetemcomitans (p = 0.002) were lower; C.rectus (p = 0.0002), P.micra (p = 0065), Streptococcus constellatus (p = 0.0151), T.denticola (p = 0.0141), P.melaninogenica (p = 0.0057), and T.socranskii (p = 0.0316) were higher in shallow pockets in the PA+PD. Diversity decreased in PD (p = 0.001) and PA+PD (p = 0.026) compared to control, with minimal differences in alpha and beta diversities among PD and PA+PD based on NGS results. Conclusion: These data demonstrated that Parkinson’s disease modifies PD-associated subgingival microbiome. | en_US |
dc.description.sponsorship | National Institutes of Health ; National Institute on Aging | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor and Francis Ltd. | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution-NonCommercial 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | Checkerboard | en_US |
dc.subject | Microbiome | en_US |
dc.subject | Microbiota | en_US |
dc.subject | Parkinson’s Disease | en_US |
dc.subject | Pathogenesis | en_US |
dc.subject | Periodontitis | en_US |
dc.title | Parkinson’s disease alters the composition of subgingival microbiome | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Oral Microbiology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0001-7409-1484 | en_US |
dc.authorid | 0000-0001-7986-7085 | en_US |
dc.authorid | 0000-0002-7712-738X | en_US |
dc.authorid | 0000-0002-8811-2263 | en_US |
dc.identifier.volume | 15 | en_US |
dc.identifier.issue | 1 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1080/20002297.2023.2250650 | en_US |
dc.institutionauthor | Yılmaz, Melis | |
dc.institutionauthor | Toygar, Hilal | |
dc.institutionauthor | Balcı, Nur | |
dc.institutionauthor | Bolluk Kılıç, Başak | |
dc.institutionauthor | Zırh, Ali | |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.wos | 001056897300001 | en_US |
dc.identifier.scopus | 2-s2.0-85169307809 | en_US |
dc.identifier.pmid | 37649970 | en_US |
dc.identifier.scopusquality | Q1 | en_US |