Prospective analysis of febrile neutropenia patients with bacteraemia: The results of an international ID-IRI study
![Thumbnail](/xmlui/themes/Mirage2//images/restricted.png)
View/ Open
Access
info:eu-repo/semantics/embargoedAccessDate
2023Author
Erdem, HakanKoçoğlu, Esra
Ankaralı, Handan
El-Sokkary, Rehab
Hakamifard, Atousa
Karaali, Rıdvan
Kulzhanova, Sholpan
Sirmatel, Fatma
Metadata
Show full item recordCitation
Erdem, H., Koçoğlu, E., Ankaralı, H., El-Sokkary, R., Hakamifard, A., Karaali, R. ... Sirmatel, F. (2023). Prospective analysis of febrile neutropenia patients with bacteraemia: The results of an international ID-IRI study. International Journal of Antimicrobial Agents, 62(3), 106919-106919. https://dx.doi.org/10.1016/j.ijantimicag.2023.106919Abstract
OBJECTIVES: Bacteraemia during the course of neutropenia is often fatal. We aimed to identify factors predicting mortality to have an insight into better clinical management. METHODS: The study has a prospective, observational design using pooled data from febrile neutropenia patients with bacteraemia in 41 centres in 16 countries. Polymicrobial bacteraemias were excluded. It was performed through the Infectious Diseases-International Research Initiative platform between 17 March 2021 and June 2021. Univariate analysis followed by a multivariate binary logistic regression model was used to determine independent predictors of 30-d in-hospital mortality (sensitivity, 81.2%; specificity, 65%). RESULTS: A total of 431 patients were enrolled, and 85 (19.7%) died. Haematological malignancies were detected in 361 (83.7%) patients. Escherichia coli (n = 117, 27.1%), Klebsiellae (n = 95, 22% %), Pseudomonadaceae (n = 63, 14.6%), Coagulase-negative Staphylococci (n = 57, 13.2%), Staphylococcus aureus (n = 30, 7%), and Enterococci (n = 21, 4.9%) were the common pathogens. Meropenem and piperacillin-tazobactam susceptibility, among the isolated pathogens, were only 66.1% and 53.6%, respectively. Pulse rate (odds ratio [OR], 1.018; 95% confidence interval [CI], 1.002-1.034), quick SOFA score (OR, 2.857; 95% CI, 2.120-3.851), inappropriate antimicrobial treatment (OR, 1.774; 95% CI, 1.011-3.851), Gram-negative bacteraemia (OR, 2.894; 95% CI, 1.437-5.825), bacteraemia of non-urinary origin (OR, 11.262; 95% CI, 1.368-92.720), and advancing age (OR, 1.017; 95% CI, 1.001-1.034) were independent predictors of mortality. Bacteraemia in our neutropenic patient population had distinctive characteristics. The severity of infection and the way to control it with appropriate antimicrobials, and local epidemiological data, came forward. CONCLUSIONS: Local antibiotic susceptibility profiles should be integrated into therapeutic recommendations, and infection control and prevention measures should be prioritised in this era of rapidly increasing antibiotic resistance.
WoS Q Kategorisi
Q1xmlui.dri2xhtml.METS-1.0.item-scopusquality
Q1Source
International Journal of Antimicrobial AgentsVolume
62Issue
3Collections
- Makale Koleksiyonu [3790]
- PubMed İndeksli Yayınlar Koleksiyonu [4251]
- Scopus İndeksli Yayınlar Koleksiyonu [6601]
- WoS İndeksli Yayınlar Koleksiyonu [6677]