Predictive factor for lymph node metastasis in non-metastatic colorectal adenocarcinomas
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Erişim
info:eu-repo/semantics/openAccessAttribution-NonCommercial 4.0 Internationalhttps://creativecommons.org/licenses/by-nc/4.0/Tarih
2022Yazar
Karcı, EbruÜrün, Yüksel
Köksoy, Elif Berna
Uçar, Gökhan
Bilgin, Burak
Yekedüz, Emre
Arslan, Çağatay
Alkan, Ali
Dede, İsa
Tuncay, Gülseren
Hocazade, Cemil
Yıldırım Özdemir, Nuriye
Şendur, Mehmet Ali Nahit
Utkan, Güngör
Yalçın, Bülent
Akbulut, Hakan
Üst veri
Tüm öğe kaydını gösterKünye
Karcı, E., Ürün, Y., Köksoy, E. B., Uçar, G., Bilgin, B., Yekedüz, E. ... Akbulut, H. (2022). Predictive factor for lymph node metastasis in non-metastatic colorectal adenocarcinomas. Eurasian Journal of Medical Investigation, 6(3), 279-283. https://dx.doi.org/10.14744/ejmi.2022.37065Özet
Objectives: To evaluate the predictive factors of lymph node involvement in non-metastatic colorectal adenocarcinomas (nmCRC). Methods: A total of 453 patients diagnosed with nmCRC were analyzed regarding T stage, lymphovascular invasion status, tumor grade and proposed risk score (RS), determined by the combination of these three factors for lymph node metastasis. Results: The median age was 62 (25-90 years), M/F ratio was 1.4:1 and majority of the patients had tumors localized on the left colon (70.6%). The number of excised lymph nodes was ≥12 in 77% of the cases. The postoperative pathological assessments revealed that 57.2% of patie,nts had N0 disease, 29.1% had N1 disease, and 13.7% had N2 disease. The T stages (p=0.007), grade (p<0.001), lymphovascular invasion (p=0.002), RS (p<0.001), and number of excised lymph nodes (p=0.029) were significantly different between N0, N1, and N2 patients. Higher RS was associated with lymph node metastasis (p<0.001). Conclusion: The risk score may predict lymph node metastasis in patients with nmCRC and if validated may be helpful in the decision-making of adjuvant chemotherapy, especially in the elderly and patients with inadequate lymph node dissection.
Kaynak
Eurasian Journal of Medical InvestigationCilt
6Sayı
3Koleksiyonlar
- Makale Koleksiyonu [3664]
- TR-Dizin İndeksli Yayınlar Koleksiyonu [2175]