Tissue factor and vascular endothelial growth factor in detecting thromboembolic complications in diabetic atherosclerotic patients
View/ Open
Access
info:eu-repo/semantics/openAccessAttribution-NonCommercial 4.0 Internationalhttps://creativecommons.org/licenses/by-nc/4.0/Date
2023Author
Alkan Bozkaya, TijenAteş, Şanser
Üstündağ, Ünsal Veli
Çakıcı, Çağrı
Keskin, İlknur
Yiğit, Pakize
Yiğitbaşı, Ahmet
Emekli, Nesrin
Metadata
Show full item recordCitation
Alkan Bozkaya, T., Ateş, Ş., Üstündağ, Ü. V., Çakıcı, Ç., Keskin, İ., Yiğit, P. ... Emekli, N. (2023). Tissue factor and vascular endothelial growth factor in detecting thromboembolic complications in diabetic atherosclerotic patients. Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, 17. https://doi.org/10.1177/11795484231167737Abstract
BackgroundAtherosclerosis, which is one of the leading causes of death all over the world, can create major or minor thromboembolic complications with the exponentially increasing diabetic status. Despite all the studies, the mechanism by which endothelial damage in atherosclerosis is triggered in diabetic setting is still not fully understood. MethodsIn this study, tissue factor (TF), which is thought to act together in the formation of vasular endothelial growth factor (VEGF-A) and coagulopathy in diabetic atherosclerotic patients, may be an important indicator in this regard, a total of 100 cases who were undergone off-pump coronary artery bypass (OPCAB) which were at same risk group examined by dividing into diabetic status. Early postoperative process and biochemical parameters analyzed in terms of TF and VEGF-A levels measured before and after the operation. ResultsTF and VEGF-A expression of the T1DM group were statistically high compared to non-diabetics. Significantly longer hospital stays with changes in TF and VEGF-A were found in patients in the diabetic group compared to pre- and postoperatively, respectively; TF (95% CI: 0.879-0.992; p = 0.025), VEGF-A (95% CI: 0.964-0.991; p = 0.001) and hospital stay (95% CI: 1.96-7.49; p = 0.0001). Preoperatively measured carotid intima-media thickness (CT) was higher in diabetics and was significantly associated with atrial fibrillation (AF), (r = 0.873). Surgical team and protocols were same and OPCAB procedures were routinely applied to all patients in our clinic. No minor or major events were observed in any of the cases. ConclusionTF and VEGF-A values in patients with diabetic atherosclerosis may be important in the early detection of thromboembolic complications.
Source
Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary MedicineVolume
17Collections
- Diğer Yayınlar Koleksiyonu [257]
- Makale Koleksiyonu [3672]
- PubMed İndeksli Yayınlar Koleksiyonu [4080]
- Scopus İndeksli Yayınlar Koleksiyonu [6346]
- WoS İndeksli Yayınlar Koleksiyonu [6465]