dc.contributor.author | Tanrıverdi, Cafer | |
dc.contributor.author | Nurözler Tabakçı, Burcu | |
dc.contributor.author | Dönmez, Sümbüle | |
dc.date.accessioned | 2023-01-04T07:09:11Z | |
dc.date.available | 2023-01-04T07:09:11Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Tanrıverdi, C., Nurözler Tabakçı, B. ve Dönmez, S. (2022). Longitudinal assessment of meibomian glands and tear film layer in systemic isotretinoin treatment. European Journal of Ophthalmology, 32(2), 885-893. https://dx.doi.org/10.1177/11206721211018361 | en_US |
dc.identifier.issn | 1120-6721 | |
dc.identifier.issn | 1724-6016 | |
dc.identifier.uri | https://dx.doi.org/10.1177/11206721211018361 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/10234 | |
dc.description.abstract | Purpose: This study aimed to analyze the changes in meibomian glands (MGs) and tear film layer over time in patients taking systemic isotretinoin treatment. Methods: Patients who received systemic isotretinoin treatment between 4 and 8 months were prospectively followed up. In addition to full ophthalmologic examination, MG dysfunction (MGD), noncontact meibography, noninvasive and invasive tear break-up time (TBUT), ocular surface disease index (OSDI), corneal staining, and eyelid margin abnormality scores were recorded before, during, and after treatment. Results: A total of 88 eyes of 88 patients were included in the study. The right eyes of all the patients were included. The mean age of the patients was 21 +/- 2.9 years. Of the 88 patients, 70 (79.6%) were females and 18 (20.4%) were males. Before the treatment, MGD, noncontact meibography, first noninvasive TBUT, mean noninvasive TBUT, invasive TBUT, OSDI, corneal staining, and eyelid margin abnormality scores were 0.29 +/- 0.45, 4.93 +/- 3.50, 13.78 +/- 3.89 s, 14.47 +/- 3.09 s, 12.96 +/- 3.61 s, 0.54 +/- 1.00, 0.04 +/- 0.20, and 0.09 +/- 0.28, respectively. Twelve months after the end of treatment, the scores were 0.97 +/- 0.87 (p < 0.001), 9.62 +/- 3.89 (p < 0.001), 11.24 +/- 3.52 s (p < 0.001), 12.34 +/- 3.02 s (p < 0.001), 11.31 +/- 2.90 s (p < 0.001), 1.90 +/- 2.44 (p < 0.001), 0.20 +/- 0.40 (p < 0.001), and 0.56 +/- 0.49 (p < 0.001), respectively. Conclusion: Systemic isotretinoin treatment causes morphological changes in the MGs. However, this treatment may negatively affect the tear film layer of patients. Some of these changes may persist for a long time even if the treatment is discontinued. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SAGE Publications Ltd | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Isotretinoin | en_US |
dc.subject | Ocular Surface Disease Index | en_US |
dc.subject | Tear Break-Up Time | en_US |
dc.subject | Meibomian Glands | en_US |
dc.subject | Meibography | en_US |
dc.subject | Dry Eye | en_US |
dc.title | Longitudinal assessment of meibomian glands and tear film layer in systemic isotretinoin treatment | en_US |
dc.type | article | en_US |
dc.relation.ispartof | European Journal of Ophthalmology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-2445-6339 | en_US |
dc.identifier.volume | 32 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 885 | en_US |
dc.identifier.endpage | 893 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1177/11206721211018361 | en_US |
dc.institutionauthor | Tanrıverdi, Cafer | |
dc.institutionauthor | Dönmez, Sümbüle | |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.wos | 000677790300001 | en_US |
dc.identifier.scopus | 2-s2.0-85106438576 | en_US |
dc.identifier.pmid | 34011178 | en_US |
dc.identifier.scopusquality | Q2 | en_US |