dc.contributor.author | Baard, Joyce | |
dc.contributor.author | Shariat, Shahrokh F. | |
dc.contributor.author | Roupret, Morgan | |
dc.contributor.author | Yoshida, Takashi | |
dc.contributor.author | Saita, Alberto | |
dc.contributor.author | Saltirov, Iliya | |
dc.contributor.author | Burgos, Javier Revilla | |
dc.contributor.author | Çelik, Orçun | |
dc.contributor.author | de la Rosette, Jean J. M. C. H. | |
dc.contributor.author | del Pilar Laguna Pes, Maria | |
dc.date.accessioned | 2022-12-15T12:39:25Z | |
dc.date.available | 2022-12-15T12:39:25Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Baard, J., Shariat, S. F., Roupret, M., Yoshida, T., Saita, A., Saltirov, I. ... del Pilar Laguna Pes, M. (2022). Adherence to guideline recommendations in the management of upper tract urothelial carcinoma: An analysis of the CROES-UTUC registry. World Journal of Urology, 40(11), 2755-2763. https://doi.org/10.1007/s00345-022-04168-z | en_US |
dc.identifier.issn | 0724-4983 | |
dc.identifier.issn | 1433-8726 | |
dc.identifier.uri | https://doi.org/10.1007/s00345-022-04168-z | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/10131 | |
dc.description.abstract | Background: The European Association of Urology provides Clinical Practice Guideline on upper tract urothelial carcinoma (UTUC). Due to the rarity of UTUC, guidelines are necessary to help guide decision-making based on the highest quality of care evidence available. Objectives: To evaluate guideline adherence in the management of UTUC by assessing recommendations on diagnostics needed for risk classification and subsequent treatment selection; to assess predictors for the latter. Participants: Data from the Clinical Research Office of the Endo Urology Society UTUC-registry were included for analysis. Statistical analysis: Overall compliance were evaluated by cross-tables, differences in risk groups characteristics and treatment selection were assessed by Chi-square tests, predictors for treatment selection by logistic regression analysis. Results: Data from 2380 patients were included. Imaging by CT-scan had highest adherence (85%) but was low for other diagnostics (17.7–49.7%). Multivariable regression analysis showed higher odds of receiving radical nephroureterectomy in patients with large tumours (OR 5.45, 95% CI 3.77–7.87, p < 0.001), signs of invasion (OR 3.07,CI 2.11–4.46, p < 0.001), high tumour grade (OR 2.05, CI 1.38–3.05, p < 0.001) and multifocality (OR 1.76,CI 1.05–2.97, p =0.032). Conclusions: CT-imaging is the most used and most impactful decision tool for risk-stratification and treatment selection in UTUC. Due to the low compliance in most of the diagnostic recommendations, proper risk stratification is not possible in a significant group of patients raising the question whether current stratification is deemed applicable in daily practice. Established prognostic factors on survival guides decision-making regarding radical versus kidney-sparing surgery. Tumour size was the most influencing factor on treatment decision. Clinical trial registration: The study was registered at ClinicalTrials.gov (ClinicalTrials.gov NCT02281188; https://clinicaltrials.gov/ct2/show/NCT02281188). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Clinical Practice Guidelines | en_US |
dc.subject | Guidelines | en_US |
dc.subject | Upper Tract Urothelial Carcinoma | en_US |
dc.subject | Urothelial Carcinoma | en_US |
dc.title | Adherence to guideline recommendations in the management of upper tract urothelial carcinoma: An analysis of the CROES-UTUC registry | en_US |
dc.type | article | en_US |
dc.relation.ispartof | World Journal of Urology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı | en_US |
dc.identifier.volume | 40 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.startpage | 2755 | en_US |
dc.identifier.endpage | 2763 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1007/s00345-022-04168-z | en_US |
dc.institutionauthor | de la Rosette, Jean J. M. C. H. | |
dc.institutionauthor | del Pilar Laguna Pes, Maria | |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.wos | 000864308300001 | en_US |
dc.identifier.scopus | 2-s2.0-85139444917 | en_US |
dc.identifier.pmid | 36197507 | en_US |
dc.identifier.scopusquality | Q1 | en_US |