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Biochemical and proteomic analysis of a potential anticancer agent: Palladium(II) saccharinate complex of terpyridine acting through double strand break formation
Adıgüzel, Zelal; Baykal, Ahmet Tarık; Kaçar, Ömer; Yılmaz, Veysel Turan; Ulukaya, Engin; Açılan, Ceyda (American Chemical Society, 2014)Metal based chemotherapeutic drugs are widely used as an effective method to defeat various cancers. In this study, the mechanism of action of a novel therapeutic agent, [Pd(sac)(terpy)](sac)center dot 4H(2)O (sac = ... -
Evaluation of apoptotic molecular pathways for smooth muscle cells isolated from thoracic aortic aneurysms in response to oxidized sterols
Adıgüzel, Zelal; Arda, Nazlı; Kaçar, Ömer; Serhatlı, Müge; Gezer Taş, Serpil; Baykal, Ahmet Tarık; Baysal, Kemal; Açılan, Ceyda (Springer, 2014)Oxysterols, oxygenated derivatives of cholesterol, are found abundantly in the plasma and atherosclerotic plaques, a common risk factor for thoracic aortic aneurysms (TAAs). Among the oxysterols, namely 7-ketocholesterol ... -
A preliminary proteomic evaluation of smooth muscle cells in thoracic aortic aneurysms
Açılan Ayhan, Ceyda; Baykal, Betül; Serhatlı, Müge; Kaçar, Ömer; Adıgüzel, Zelal; Taş, Serpil; Baysal, Kemal; Baykal, Ahmet Tarık (The Scientific and Technological Research Council of Turkey, 2014)Aortic aneurysm is characterized as localized degeneration of the aorta leading to advanced weakening and widening of the vessel. While the exact mechanisms have yet to be determined, current studies indicate that the ...