Browsing by Author "Demirayak, Şeref"
Now showing items 21-40 of 55
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Novel thiazole-piperazine derivatives as potential cholinesterase inhibitors
Demirayak, Şeref; Şahin, Zafer; Ertaş, Merve; Bülbül, Emre Fatih; Bender, Ceysu; Biltekin, Sevde Nur; Berk, Barkın; Sağlık, Begüm Nurpelin; Levent, Serkan; Yurttaş, Leyla (Wiley, 2019)Dementia is a cognitive disorder mostly associated with Alzheimer's disease (AD) in addition to being seen in many other diseases of the central nervous system (CNS). The limited number of drugs is not sufficient to provide ... -
Platinum(II)-thiosemicarbazone drugs override the cell resistance due to glutathione; assessment of their activity against human adenocarcinoma cells
Poyraz, Mehmet; Demirayak, Şeref; Banti, Christina N.; Manos, Manolis J.; Kourkoumelis, Nikolaos; Hadjikakou, Sotiris K. (Taylor & Francis Ltd, 2016)New platinum(II) compounds of the thiosemicarbazone 1-(1H-Benzimidazol-2-yl)ethan-1-one thiosemicarbazone (BzimetTSCH), [Pt(BzimetTSCH)Cl]center dot 2H(2)O (1) and [Pt(BzimetTSCH)(tpp)]Cl center dot H2O center dot MeCN (2) ... -
Potent ribonucleotide reductase inhibitors: Thiazole-containing thiosemicarbazone derivatives
Ertaş, Merve; Şahin, Zafer; Bülbül, Emre Fatih; Bender, Ceysu; Biltekin, Sevde Nur; Berk, Barkın; Yurttaş, Leyla; Nalbur, Aysu M.; Çelik, Hayati; Demirayak, Şeref (Wiley, 2019)The antioxidant, antimalarial, antibacterial, and antitumor activities of thiosemicarbazones have made this class of compounds important for medicinal chemists. In addition, thiosemicarbazones are among the most potent and ... -
Pyridine-substituted thiazolylphenol derivatives: Synthesis, modeling studies, aromatase inhibition, and antiproliferative activity evaluation
Ertaş, Merve; Şahin, Zafer; Berk, Barkın; Yurttaş, Leyla; Biltekin, Sevde Nur; Demirayak, Şeref (Wiley-VCH Verlag, 2018)Drugs used in breast cancer treatments target the suppression of estrogen biosynthesis. During this suppression, the main goal is to inhibit the aromatase enzyme that is responsible for the cyclization and structuring of ... -
A quantum chemical DFT/HF study on acidity constants of some benzothiazole and thiazole derivatives
Tay, Funda; Duran, Murat; Demirayak, Şeref (Council of Scientific and Industrial Research, 2014)The acid dissociation (K-a) constants of some 4-and/or 6-substituted-2-aminobenzothiazole compounds have been investigated theoretically. The gas and aqueous phase geometries, thermal and solvation free energies have been ... -
Studies on non-steroidal inhibitors of aromatase enzyme; 4-(aryl/heteroaryl)-2-(pyrimidin-2-yl)thiazole derivatives
Şahin, Zafer; Ertaş, Merve; Berk, Barkın; Biltekin, Sevde Nur; Yurttaş, Leyla; Demirayak, Şeref (Pergamon-Elsevier Science Ltd, 2018)Steroidal and non-steroidal aromatase inhibitors target the suppression of estrogen biosynthesis in the treatment of breast cancer. Researchers have increasingly focused on developing non-steroidal derivatives for their ... -
Synthesis and anti-cancer activity evaluation of new aurone derivatives
Demirayak, Şeref; Yurttaş, Leyla; Gündoğdu Karaburun, Nalan; Karaburun, Ahmet Çağrı; Kayagil, İsmail (Taylor and Francis, 2015)In this study, we have synthesized 2-[3-or 4-(2-aryl-2-oxoethoxy) arylidene] benzofuran-3-one derivatives (D1-D38) and evaluated their anti-cancer activities. The final compounds were obtained in multistep synthesis reactions ... -
Synthesis and antibacterial evaluation of novel benzimidazole, benzothiazole, benzofurane, and naphtofurane derivatives of aminothiazoles
Şahin, Zafer; Tok, Büşra Işıl; Akgün, Erol; Çaşkurlu, Ayşegül; Yurttaş, Leyla; Berk, Barkın; Demirayak, Şeref (Ankara Association of Pharmaceutical Sciences, 2022)The thiazole ring is the core of bioactive molecules that generate broad activity. These activities include anticonvulsant, antimicrobial, antituberculosis, antiviral, etc. In this work, starting from seconder/cyclic amines, ... -
Synthesis and anticancer activity of some 1,2,3-trisubstituted pyrazinobenzimidazole derivatives
Demirayak, Şeref; Yurttas, Leyla (Taylor & Francis, 2014)The synthesis of some new pyrazino[1,2-a]benzimidazole derivatives and investigation of their anticancer activities were aimed in this work. Thus, 2-acetylbenzimidazole was reacted with appropriate alpha-bromoacetophenones ... -
Synthesis and anticancer activity of some 1H-inden-1-one substituted (heteroaryl)acetamide derivatives
Karaburun, Ahmet Çağrı; Gündoğdu-Karaburun, Nalan; Yurttaş, Leyla; Kayagil, İsmail; Demirayak, Şeref (Bentham Science Publishers Ltd., 2019)Background: The synthesis of 2-[3/4-((6-substituted-1-oxo-2,3-dihydro-1H-inden-2ylidene) methyl)phenoxy]-N-(heteroaryl)acetamide derivatives and the investigation of their anticancer activity were studied. Methods: ... -
Synthesis and anticancer activity of some 2-[3/4-(2-substituted phenyl-2-oxoethoxy)benzylidene]-6-substituted-2,3-dihydro-1H-inden-1-one derivatives
Gündoğdu-Karaburun, Nalan; Karaburun, Ahmet Çağrı; Demirayak, Şeref; Kayagil, İsmail; Yurttaş, Leyla (Bentham Science Publishers, 2014)The synthesis of 2-[3/ 4-(2-substituted phenyl-2-oxoethoxy) benzylidene]-6-substituted-2,3-dihydro-1H-inden-1one derivatives and the investigation of their anticancer activity were studied. 2-(3- or 4-Hydroxybenzylidene) ... -
Synthesis and antifungal activities of some aryl naphthofuran ketoximes
Karaburun, Ahmet Çağrı; Gündoğdu Karaburun, Nalan; Uçucu, Ümit; Demirayak, Şeref (Bentham Science, 2011)In this study, some aryl naphtho[2, 1-b]furan-2-yl ketoximes and their ethers and esters were synthesised. The structure elucidation of the compounds was performed by IR, 1H-NMR and MASS spectroscopic data and elemental ... -
Synthesis and antifungal activity evaluation of New 1,2,4-triazole derivatives bearing salicylidene hydrazide moiety
Demirayak, Şeref; Kayagil, İsmail; Yurttaş, Leyla; Er, Sevda (Bentham Science Publ Ltd, 2016)A series of new N'-(arylidene)-2-[(1-(4-nitrophenyl)-1H-1,2,4-triazol-3-yl)oxy]acetohydrazide derivatives (116) were prepared and tested for theira ntifungal activity against six plant pathogens, three human pathogens and ... -
Synthesis and antimicrobial activity evaluation of novel nitrofuranthiazoles
Yurttaş, Leyla; Şahin, Zafer; Er, Sevda; Demirayak, Şeref (University of Istanbul, 2016)In this work, six novel 4-aryl-2-[2-((5-nitrofuran-2-yl)methylene)hydrazinyl] thiazole derivatives (2a-f) were synthesized starting from 5-nitro-2-furaldehyde diacetate by using Hantzsch thiazole synthesis. The antimicrobial ... -
Synthesis and antimycobacterial activity evaluation of isatin-derived 3- [(4-aryl-2-thiazolyl])hydrazone]-1H-indol-2,3-diones
Yurttaş, Leyla; Ertaş, Merve; Cankılıç Yılmaz, Meral; Demirayak, Şeref (University of Istanbul, 2017)A series of 3-[(4-aryl-2-thiazolyl)hydrazone]-1H-indol-2,3-dione derivatives (2a-f) were designed and synthesized using isatin as starting material. The obtained thiazole compounds were screened to investigate their ... -
Synthesis and antiproliferative activity of 2-arylidene 6-(2-aryl-2-oxoethoxy) benzofuran-3-one derivatives
Demirayak, Şeref; Yurttaş, Leyla; Karaburun, Ahmet Cağrı; Gündoğdu Karaburun, Nalan; Kayagil, İsmail (Bentham Science Publ Ltd, 2016)The synthesis of 2-arylidene 6-(2-aryl-2-oxoethoxy) benzofuran-3-one derivatives was reported and selected compounds were determined for their anticancer activity evaluation in National Cancer Institute NCI, USA according ... -
Synthesis and antitumor activity evaluation of new 2-(4-aminophenyl)benzothiazole derivatives bearing different heterocyclic rings
Yurttaş, Leyla; Tay, Funda; Demirayak, Şeref (Taylor & Francis, 2015)Twenty-five new N-[4-(benzothiazole-2-yl)phenyl]acetamide derivatives bearing different heterocyclic ring systems were synthesized using 2-(4-aminophenyl)benzothiazole structure as a pharmacophoric group. Final compounds ... -
Synthesis and biological evaluation of some 1,2-disubstituted benzimidazole derivatives as new potential anticancer agents
Yurttaş, Leyla; Demirayak, Şeref; Çiftçi Akalın, Gülşen; Yıldırım Ulusoylar, Şafak; Kaplancıklı, Zafer Asım (2013)The synthesis of some new 1-(2-aryl-2-oxoethyl)-2-[(morpholine-4-yl)thioxomethyl]benzimidazole derivatives and investigation of their anticancer activities were the aims of this work. 2-(Chloromethyl)benzimidazole compound ... -
Synthesis and characterization of novel oxime derivatives
Arslan, Taner; Keskin, Serhat; Demirayak, Şeref (Bentham Science Publ Ltd, 2016)Background: The synthesis of effective drugs are very important for the scientist. The various biological effects of the thiazole, oxime and ether functional groups are well known properties by the drug developers. So we ... -
Synthesis and characterizations of novel thiazolyl-thiadiazole derivatives as telomerase activators
Kayagil, İsmail; Mutlu, Ayşe Gül; Bayhan, Ülkü; Yılmaz, İnanç; Demirayak, Şeref (Scientific Technical Research Council Turkey-Tubitak, 2018)Pyridine-3/4-thiocarboxamide derivatives were used as starting materials for the synthesis of the target compounds. The pyridine-3/4-thiocarboxamide derivatives were reacted with ethyl 2-chloroacetoacetate in ethanol to ...