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dc.contributor.authorErşahin, Aynur Adeviye
dc.contributor.authorAcet, Mustafa
dc.contributor.authorAcet, Tuba
dc.contributor.authorYavuz, Yasemin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:51Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:51Z
dc.date.issued2016en_US
dc.identifier.citationErşahin, A. A., Acet, M., Acet, T. ve Yavuz, Y. (2016). Disturbed endometrial NF-κB expression in women with recurrent implantation failure. European Review for Medical and Pharmacological Sciences, 20(24), 5037-5040.en_US
dc.identifier.issn1128-3602
dc.identifier.urihttps://hdl.handle.net/20.500.12511/971
dc.description.abstractOBJECTIVE: This study was planned to investigate whether expression levels of endometrial NF-κB1 and NFκB p65 changes in women with recurrent implantation failure (RIF). PATIENTS AND METHODS: The study group consists of 30 RIF patients having at least three previous failed IVF cycles. The control group comprises of 30 patients having one or no previous failed attempt. Endometrial samples were obtained from all participants during hysteroscopy at the late follicular phase. Samples underwent ELISA analysis and immunohistochemical staining. The semi-quantitative H-Score method was used for analyzing the intensity of endometrial NF-κB p65 expression. RESULTS: The concentrations of endometrial NF-κB1 were found to be significantly increased when compared to control subjects. Likewise, significantly increased NF-κB p65 immunoreactivity was detected in the cytoplasm of luminal and glandular epithelial cells. The H-Score of NF- κB p65 in RIF women was found to be significantly increased when compared to control group. CONCLUSIONS: Increased levels of NF-κB1 and NF-κB p65 in the endometrium of RIF women can disturb physiological inflammation which is known to be positive modulator of endometrial receptivity.en_US
dc.language.isoengen_US
dc.publisherVerduci Publisheren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInflammationen_US
dc.subjectNF-κB p65en_US
dc.subjectNF-κB1en_US
dc.subjectRIFen_US
dc.titleDisturbed endometrial NF-κB expression in women with recurrent implantation failureen_US
dc.typearticleen_US
dc.relation.journalEuropean Review for Medical and Pharmacological Sciencesen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.identifier.volume20en_US
dc.identifier.issue24en_US
dc.identifier.startpage5037en_US
dc.identifier.endpage5040en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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