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dc.contributor.authorToprak, Güven
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorÇakır, Tansel
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorVelioğlu, Halil Aziz
dc.contributor.authorYuluğ, Burak
dc.date.accessioned2022-06-03T08:17:53Z
dc.date.available2022-06-03T08:17:53Z
dc.date.issued2022en_US
dc.identifier.citationToprak, G., Hanoğlu, L., Çakır, T., Güntekin, B., Velioğlu, H. A. ve Yuluğ, B. (2022). DLPF targeted repetitive transcranial magnetic stimulation improves brain glucose metabolism along with the clinical and electrophysiological parameters in CBD patients. Endocrine, Metabolic and Immune Disorders - Drug Targets, 22(4), 415-424. https://doi.org/10.2174/1871530322666220131120349en_US
dc.identifier.issn1871-5303
dc.identifier.issn2212-3873
dc.identifier.urihttps://doi.org/10.2174/1871530322666220131120349
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9493
dc.description.abstractBackground: Corticobasal Degeneration (CBD) is a rare neurological disease caused by the pathological accumulation of tau protein. The primary pathological features of CBD include progressive neurodegenerative processes resulting in remarkable frontoparietal and basal ganglia at-rophy. Objective: Like in many other neurodegenerative disorders, there is still no effective disease-modi-fying drug therapy in CBD. Therefore, the development of new treatment methods is of great im-portance. In this study, we aimed to assess the stimulating effects of high-frequency DLPFC rTMS on the motor, cognitive and behavioral disturbances in four CBD patients. Methods: Four (three females, one male) CBD patients who had been diagnosed as CBD were en-rolled in this study. Patients were evaluated before and after the rTMS procedure regarding the mo-tor, neuropsychometric and behavioral tests. The results of statistical analysis of behavioral and neuropsychometric evaluation were assessed via SPSS 18.0 package program. Data are expressed as mean, standard deviation. Before and after values of the groups were compared with the Wilcox-on sign rank test, and p<0.05 was considered significant. Results: We have provided strong preliminary evidence that the improvement in clinical parameters was associated with the normalizations of the theta activity and glucose metabolism. Conclusion: Our current results are consistent with some previous trials showing a strong association between DLPFC targeted rTMS and electrophysiological normalizations in the left DLPFC.en_US
dc.language.isoengen_US
dc.publisherBentham Science Publishersen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectBehavioral Scoresen_US
dc.subjectCBDen_US
dc.subjectCognitive Scoresen_US
dc.subjectFDG-PETen_US
dc.subjectQEEGen_US
dc.subjectrTMSen_US
dc.titleDLPF targeted repetitive transcranial magnetic stimulation improves brain glucose metabolism along with the clinical and electrophysiological parameters in CBD patientsen_US
dc.typearticleen_US
dc.relation.ispartofEndocrine, Metabolic and Immune Disorders - Drug Targetsen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nükleer Tıp Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsüen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.authorid0000-0003-4856-9987en_US
dc.authorid0000-0003-4292-5717en_US
dc.authorid0000-0002-7685-2766en_US
dc.authorid0000-0002-0860-0524en_US
dc.authorid0000-0002-2306-5937en_US
dc.identifier.volume22en_US
dc.identifier.issue4en_US
dc.identifier.startpage415en_US
dc.identifier.endpage424en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.2174/1871530322666220131120349en_US
dc.institutionauthorToprak, Güven
dc.institutionauthorHanoğlu, Lütfü
dc.institutionauthorÇakır, Tansel
dc.institutionauthorGüntekin, Bahar
dc.institutionauthorVelioğlu, Halil Aziz
dc.identifier.wosqualityQ4en_US
dc.identifier.wos000834703400006en_US
dc.identifier.scopus2-s2.0-85130617567en_US
dc.identifier.pmid35100961en_US
dc.identifier.scopusqualityQ3en_US


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