dc.contributor.author | Günbey, Ceren | |
dc.contributor.author | Bilginer, Burçak | |
dc.contributor.author | Karlı Oğuz, Kader | |
dc.contributor.author | Söylemezoğlu, Figen | |
dc.contributor.author | Ergün, Eser Lay | |
dc.contributor.author | Akalan, Nejat | |
dc.contributor.author | Topçu, Meral | |
dc.contributor.author | Turanlı, Güzide | |
dc.contributor.author | Yalnızoğlu, Dilek | |
dc.date.accessioned | 2022-05-12T11:26:23Z | |
dc.date.available | 2022-05-12T11:26:23Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Günbey, C., Bilginer, B., Karlı Oğuz, K., Söylemezoğlu, F., Ergün, E. L., Akalan, N. ... Yalnızoğlu, D. (2022). Lesional resective epilepsy surgery in childhood: Comparison of two decades and long-term seizure outcome from a single center. Epilepsy Research, 181. https://doi.org/10.1016/j.eplepsyres.2022.106882 | en_US |
dc.identifier.issn | 0920-1211 | |
dc.identifier.issn | 1872-6844 | |
dc.identifier.uri | https://doi.org/10.1016/j.eplepsyres.2022.106882 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/9436 | |
dc.description.abstract | Objective: Epilepsy surgery has shown efficacy in children. We aimed to assess long-term seizure outcome in children who underwent epilepsy surgery and determine predictive factors for seizure freedom.& nbsp;Methods: This is a retrospective study of 196 children who underwent epilepsy surgery between 1994 and 2015 and had a minimum postoperative follow-up of 5 years.& nbsp;Results: The median age at the time of surgery was 9.5 (0.08-19.8) years; 110 (56.1%) had temporal, 62 (31.6%) had extratemporal resections, and 24 (12.2%) had hemispheric surgery. The duration of postsurgical follow-up was between 5 and 20 years (mean +/- SD: 7 +/- 3.2). Overall, 129 of 196 (65.8%) patients had Engel class I outcome at final visit. Among patients who underwent temporal, extratemporal and hemispheric surgery; 84 of 110 (76.4%), 34 of 62 (54.8%), and 11 of 24 (45.8%) patients had complete seizure freedom, respectively (p: 0.016). Patients with tumors had the best outcome, with 83.1% seizure freedom. The number of preoperative antiseizure medications (OR 3.19, 95% CI 1.07-9.48), the absence of postoperative focal epileptiform discharges (OR 8.98, 95% CI 4.07-19.79) were independent predictors of seizure freedom. Across two decades, the age at surgery was decreased (p: 0.003), overall seizure freedom (61.8% vs 68%) did not differ. In the past decade, a higher proportion of malformations of cortical development was operated (14.7% vs 35.9%, p: 0.007).& nbsp;Significance: Our findings showed favorable long-term seizure outcome in children who underwent epilepsy surgery. The results are encouraging for developing centers with limited resources to establish pediatric epilepsy programs. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Children | en_US |
dc.subject | Epilepsy Surgery | en_US |
dc.subject | Extratemporal Resections | en_US |
dc.subject | Hemispheric Surgery | en_US |
dc.subject | Long-Term Seizure Outcome | en_US |
dc.subject | Temporal Resections | en_US |
dc.title | Lesional resective epilepsy surgery in childhood: Comparison of two decades and long-term seizure outcome from a single center | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Epilepsy Research | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-1447-9051 | en_US |
dc.identifier.volume | 181 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.eplepsyres.2022.106882 | en_US |
dc.institutionauthor | Akalan, Nejat | |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.wos | 000786607000015 | en_US |
dc.identifier.scopus | 2-s2.0-85124478734 | en_US |
dc.identifier.pmid | 35168000 | en_US |
dc.identifier.scopusquality | Q2 | en_US |