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dc.contributor.authorSaka, Burcu
dc.contributor.authorBalcı, Serdar
dc.contributor.authorBaştürk, Olca
dc.contributor.authorBağcı, Pelin
dc.contributor.authorPostlewait, Lauren Mc Lendon
dc.contributor.authorMaithel, Shishir Kumar
dc.contributor.authorKnight, Jessica
dc.contributor.authorEl Rayes, Bassel
dc.contributor.authorKooby, David
dc.contributor.authorSarmiento, Juan Martinez
dc.contributor.authorMuraki, Takashi
dc.contributor.authorOliva, Irma
dc.contributor.authorBandyopadhyay, Sudeshna
dc.contributor.authorAkkaş, Gizem
dc.contributor.authorGoodman, Michael
dc.contributor.authorReid, Michelle Dian
dc.contributor.authorKrasinskas, Alyssa
dc.contributor.authorEverett, Rhonda
dc.contributor.authorAdsay, Nazmi Volkan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:46Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:46Z
dc.date.issued2016en_US
dc.identifier.citationSaka, B., Balcı, S., Baştürk, O., Bağcı, P., Postlewait, L, M. L., Maithel, S. ... Adsay, N. V. (2016). Pancreatic ductal adenocarcinoma is spread to the peripancreatic soft tissue in the majority of resected cases, rendering the AJCC T-stage protocol (7th Edition) inapplicable and Insignificant: A size-based staging system (pT1: ?2, pT2: >2–?4, pT3: >4 cm) is more valid and clinically relevant. Annals of Surgical Oncology, 23(6), 2010-2018. https://dx.doi.org/10.1245/s10434-016-5093-7en_US
dc.identifier.issn1068-9265
dc.identifier.urihttps://hdl.handle.net/20.500.12511/941
dc.identifier.urihttps://dx.doi.org/10.1245/s10434-016-5093-7
dc.description.abstractBackground: Most studies have failed to identify any prognostic value of the current T-stage protocol for pancreatic ductal adenocarcinoma (PDAC) by the American Joint Committee on Cancer and the Union for International Cancer Control unless some grouping was performed. Methods: To document the parameters included in this T-stage protocol, 223 consecutive pancreatoduodenectomy specimens with PDAC were processed by a uniform grossing protocol. Results: Peripancreatic soft tissue (PST) involvement, the main pT3 parameter, was found to be inapplicable and irreproducible due to lack of a true capsule in the pancreas and variability in the amount and distribution of adipose tissue. Furthermore, 91 % of the cases showed carcinoma in the adipose tissue, presumably representing the PST, and thus were classified as pT3. An additional 4.5 % were qualified as pT3 due to extension into adjacent sites. The T-stage defined as such was not found to have any correlation with survival (p = 0.4). A revised T-stage protocol was devised that defined pT1 as 2 cm or smaller, pT2 as >2–4 cm, and pT3 as larger than 4 cm. This revised protocol was tested in 757 consecutive PDACs. The median and 3-year survival rates of this size-based protocol were 26, 18, 13 months, and 40 %, 26 %, 20 %, respectively (p < 0.0001). The association between higher T-stage and shorter survival persisted in N0 cases and in multivariate modeling. Analysis of the Surveillance, Epidemiology, and End Results database also confirmed the survival differences (p < 0.0001). Conclusions: This study showed that resected PDACs are already spread to various surfaces of the pancreas, leaving only about 4 % of PDACs to truly qualify as pT1/T2, and that the current T-stage protocol does not have any prognostic correlation. In contrast, as shown previously in many studies, size is an important prognosticator, and a size-based T-stage protocol is more applicable and has prognostic value in PDAC.en_US
dc.language.isoengen_US
dc.publisherSpringer New York LLCen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectPancreatic Ductal Adenocarcinomaen_US
dc.subjectSpread to the Peripancreaticen_US
dc.subjectSoft Tissueen_US
dc.subjectMajority of Resected Casesen_US
dc.titlePancreatic ductal adenocarcinoma is spread to the peripancreatic soft tissue in the majority of resected cases, rendering the AJCC T-stage protocol (7th Edition) inapplicable and Insignificant: A size-based staging system (pT1: ?2, pT2: >2–?4, pT3: >4 cm) is more valid and clinically relevanten_US
dc.typearticleen_US
dc.relation.journalAnnals of Surgical Oncologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalıen_US
dc.authorid0000-0001-6830-7701en_US
dc.identifier.volume23en_US
dc.identifier.issue6en_US
dc.identifier.startpage2010en_US
dc.identifier.endpage2018en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1245/s10434-016-5093-7en_US


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