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dc.contributor.authorMutlu Burnaz, Özlem
dc.contributor.authorÇağavi, Esra
dc.date.accessioned2022-04-22T11:06:17Z
dc.date.available2022-04-22T11:06:17Z
dc.date.issued2022en_US
dc.identifier.citationMutlu Burnaz, Ö. ve Çağavi, E. (2022). Revealing nervous and cardiac system interactions by iPSC-Based platforms. iPSCs - State of the Science içinde (1-28. ss.). Elsevier. https://doi.org/10.1016/B978-0-323-85767-3.00002-5en_US
dc.identifier.isbn9780323857673
dc.identifier.isbn9780323856454
dc.identifier.urihttps://doi.org/10.1016/B978-0-323-85767-3.00002-5
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9358
dc.description.abstractCardiac function is regulated by the autonomic nervous system. In exchange, the sensorial information from the heart is relayed to the brain via sensory neurons as a crucial modulatory feedback mechanism. Cardiovascular and neurological diseases constitute the majority of deaths globally. The high morbidity associated with cardiac and neurological disorders is mostly due to the limited number of targeted therapeutics. Moreover, many new drug candidates are withdrawn from clinical use due to cardiotoxicity or neurotoxicity. Previously, experimental animal models, biopsy materials, or immortalized cell lines were the basis of disease studies and drug screens. However, the differences between these models and human physiology particularly in neural and cardiac functions resulted in limited clinical success. To overcome the complications related to the organism mismatch and cell source, human induced pluripotent stem cells (hiPSCs) provide ways to investigate molecular mechanisms in embryonic, adult, and diseased states. hiPSC-derived cardiac cells and various neuron subtypes could replicate complex interactions in the physiologically relevant organoids or multiorgan microdevices. Using these novel technical developments, recent models of neuronal regulation of heart tissue started to provide unique insights in systemic interactions and molecular basis to develop more precise therapeutic approaches. In this chapter, a brief historical perspective and recent advances in iPSC-based models of cardiac and nervous system interactions are reviewed.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiac Differentiationen_US
dc.subjectCardiac Innervationsen_US
dc.subjectCardiologyen_US
dc.subjectCardiovascular Diseaseen_US
dc.subjectInvitro Disease Modelsen_US
dc.subjectIPSCen_US
dc.subjectMicrofluidicsen_US
dc.subjectNervous Systemen_US
dc.subjectNeural Differentiationen_US
dc.subjectOrgan-on-a-Chipen_US
dc.subjectOrganoidsen_US
dc.subjectSensory Neuronsen_US
dc.subjectTissue Engineeringen_US
dc.titleRevealing nervous and cardiac system interactions by iPSC-Based platformsen_US
dc.typebookParten_US
dc.relation.ispartofiPSCs - State of the Scienceen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsüen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Tıbbi Biyoloji ve Genetik Ana Bilim Dalıen_US
dc.authorid0000-0001-5688-136Xen_US
dc.authorid0000-0002-7199-583Xen_US
dc.identifier.startpage1en_US
dc.identifier.endpage28en_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.identifier.doi10.1016/B978-0-323-85767-3.00002-5en_US
dc.institutionauthorMutlu Burnaz, Özlem
dc.institutionauthorÇağavi, Esra
dc.identifier.scopus2-s2.0-85128085996en_US


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