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dc.contributor.authorGünal, Mehmet Yalçın
dc.contributor.authorOkçu Heper, Aylin
dc.contributor.authorZaloğlu, Nezahat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:42Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:42Z
dc.date.issued2014en_US
dc.identifier.citationGünal, M. Y., Okçu Heper, A. ve Zaloğlu, N. (2014). The effects of topical carvacrol application on wound healing process in male rats. Pharmacognosy Journal, 6(3), 10-14. https://dx.doi.org/10.5530/pj.2014.3.2en_US
dc.identifier.issn0975-3575
dc.identifier.urihttps://hdl.handle.net/20.500.12511/910
dc.identifier.urihttps://dx.doi.org/10.5530/pj.2014.3.2
dc.description.abstractCarvacrol containing products such as Origanum onites have been used as phytotherapeutic agents in the treatment of serious skin injury. It has been suggested that carvacrol is the active component of these herbs because of its anti-microbial property. With the anti-microbial activity and as an ingredient of these herbs, carvacrol is a promising molecule for the treatment of skin injury. In the present study, we have evaluated the efficacy of carvacrol on healing progress after excisional skin injury. Here, Wistar-Albino rats were divided into two groups and treated with carvacrol and vehicle. Carvacrol was administrated topically at a concentration of %12.5 for the 5 consecutive days after excisional skin injury. Tissue samples were harvested on days 3rd, 8th and 12th after injury. Significant beneficial effect of carvacrol was observed at the end of the experiment. In the acute phase of the injury, carvacrol treatment increased tissue granulation and decreased wound depth moderately. These effect of carvacrol was associated with increased TNF-?. However, at the second half of the experiment the elevated level of TGF-B1 was observed as compared with control animals. The level of IL-1ß was increased in carvacrol treated animals only on day 8. Here, we provide evidence that carvacrol improves wound healing by regulating pro- inflammatory molecules TNF-?, IL-1ß and TGF-ß1.en_US
dc.language.isoengen_US
dc.publisherEManuscript Servicesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAromatic Herbsen_US
dc.subjectCarvacrolen_US
dc.subjectIL-1ßen_US
dc.subjectTGF-ß1en_US
dc.subjectTNF-?en_US
dc.subjectWound Healingen_US
dc.titleThe effects of topical carvacrol application on wound healing process in male ratsen_US
dc.typearticleen_US
dc.relation.journalPharmacognosy Journalen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.authorid0000-0001-7702-2441en_US
dc.identifier.volume6en_US
dc.identifier.issue3en_US
dc.identifier.startpage10en_US
dc.identifier.endpage14en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.5530/pj.2014.3.2en_US


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