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dc.contributor.authorÖzçiçek, İlyas
dc.contributor.authorAyşit, Neşe
dc.contributor.authorÇakıcı, Çağrı
dc.contributor.authorUlaş Aytürk, Nilüfer
dc.contributor.authorAydeğer, Asel
dc.contributor.authorErim, Ümit Can
dc.date.accessioned2022-02-02T07:51:17Z
dc.date.available2022-02-02T07:51:17Z
dc.date.issued2022en_US
dc.identifier.citationÖzçiçek, İ., Ayşit, N., Çakıcı, Ç., Ulaş Aytürk, N., Aydeğer, A. ve Erim, Ü. C. (2022). The effects of various surface coatings of gold nanorods on toxicity, neuronal localization, microstructural alterations, and in vitro/in vivo biodistribution. Advanced Materials Interfaces, 9(3). https://dx.doi.org/10.1002/admi.202101369en_US
dc.identifier.issn2196-7350
dc.identifier.urihttps://dx.doi.org/10.1002/admi.202101369
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8949
dc.description.abstractWith the development of gold nanorods (AuNRs) for a number of biomedical applications, understanding their various biological effects has become important. Surface functionalization of AuNRs is attracting increasing attention with regard to toxicity, cellular uptake, localization, therapeutic potential, and biodistribution. The aim of the study is to synthesis of stable AuNRs functionalized with polyethylenimine (PEI) and polyethylene glycol (PEG), multiparametric investigation of their cellular effects on the dorsal root ganglion (DRG) primary sensory neurones, evaluation of the in vitro/in vivo biodistribution, and toxicity. PEI and PEG surface coatings increased both biocompatibility and biodistribution of the AuNRs. With the near-infrared laser of the two-photon microscope, very strong radiations are taken from the nucleolus parts of the neurones particularly and these localizations of the AuNRs-PEI are confirmed by the transmission electron microscope images. Inductively coupled plasma mass spectrometry analysis shows the presence of AuNRs in liver, spleen, kidney, heart, blood, and brain within a 30 day period. It is observed that the surface coatings of the AuNRs significantly increase the biodistribution and biocompatibility. The surface functionalization, stability, and biocompatibility of the AuNRs are very important parameters for the potential nanotheranostic applications of AuNRs in the next studies.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectBiodistributionen_US
dc.subjectCellular Localizationen_US
dc.subjectDorsal Root Ganglion Sensory Neuronesen_US
dc.subjectGold Nanorodsen_US
dc.subjectNanotoxicityen_US
dc.subjectPolyethylenimineen_US
dc.subjectPolyethylene Glycolen_US
dc.subjectSurface Functionalizationen_US
dc.titleThe effects of various surface coatings of gold nanorods on toxicity, neuronal localization, microstructural alterations, and in vitro/in vivo biodistributionen_US
dc.typearticleen_US
dc.relation.ispartofAdvanced Materials Interfacesen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsüen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalıen_US
dc.authorid0000-0002-8662-5284en_US
dc.authorid0000-0001-8759-745Xen_US
dc.identifier.volume9en_US
dc.identifier.issue3en_US
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/217S135
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1002/admi.202101369en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ1en_US


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