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dc.contributor.authorSertel Şelale, Deniz
dc.contributor.authorUzun, Meltem
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:37Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:37Z
dc.date.issued2018en_US
dc.identifier.citationSertel Şelale, D. ve Uzun, M. (2018). The value of microscopic-observation drug susceptibility assay in the diagnosis of tuberculosis and detection of multidrug resistance. APMIS, 126(1), 38-44. https://dx.doi.org/10.1111/apm.12783en_US
dc.identifier.issn0903-4641
dc.identifier.issn1600-0463
dc.identifier.urihttps://hdl.handle.net/20.500.12511/873
dc.identifier.urihttps://dx.doi.org/10.1111/apm.12783
dc.description.abstractInexpensive, rapid, and reliable tests for detecting the presence and drug susceptibility of Mycobacterium tuberculosis complex (MTBC) are urgently needed to control the transmission of tuberculosis. In this study, we aimed to assess the accuracy and speed of the microscopic-observation drug susceptibility (MODS) assay in the identification of MTBC and detection of multidrug resistance. Sputum samples from patients suspected to have tuberculosis were simultaneously tested with MODS and conventional culture [Löwenstein-Jensen (LJ) culture, BACTEC MGIT™ 960 (MGIT) system], and drug susceptibility testing (MGIT system) methods. A total of 331 sputum samples were analyzed. Sensitivity and specificity of MODS assay for detection of MTBC strains were 96% and 98.8%, respectively. MODS assay detected multidrug resistant MTBC isolates with 92.3% sensitivity and 96.6% specificity. Median time to culture positivity was similar for MGIT (8 days) and MODS culture (8 days), but was significantly longer with LJ culture (20 days) (p <0.0001 for both comparisons). Median time to availability of the susceptibility results was significantly (p <0.0001) shorter with MODS assay (8 days) than MGIT system (20 days). In conclusion, MODS is an inexpensive and rapid test with good performance characteristics for direct diagnosis of tuberculosis and detection of multidrug resistance.en_US
dc.description.sponsorshipIstanbul Universityen_US
dc.language.isoengen_US
dc.publisherBlackwell Munksgaarden_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectIsoniaziden_US
dc.subjectMultidrug Resistant Tuberculosisen_US
dc.subjectMycobacterium Tuberculosisen_US
dc.subjectRifampicinen_US
dc.titleThe value of microscopic-observation drug susceptibility assay in the diagnosis of tuberculosis and detection of multidrug resistanceen_US
dc.typearticleen_US
dc.relation.journalAPMISen_US
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalıen_US
dc.identifier.volume126en_US
dc.identifier.issue1en_US
dc.identifier.startpage38en_US
dc.identifier.endpage44en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1111/apm.12783en_US


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