Basit öğe kaydını göster

dc.contributor.authorÇakıcı, Çağrı
dc.contributor.authorYiğitbaşı, Türkan
dc.contributor.authorAyla, Şule
dc.contributor.authorKarimkhani, Hadi
dc.contributor.authorBayramoğlu, Feyza
dc.contributor.authorYiğit, Pakize
dc.contributor.authorKılıç, Ertuğrul
dc.contributor.authorEmekli, Nesrin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:36Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:36Z
dc.date.issued2018en_US
dc.identifier.citationÇakıcı, Ç., Yiğitbaşı, T., Ayla, Ş., Karimkhani, H., Bayramoğlu, F., Yiğit, P. ... Emekli, N. (2018). Dose-dependent effects of vitamin 1,25(OH)2D3 on oxidative stress and apoptosis. Journal of Basic and Clinical Physiology and Pharmacology, 29(3), 271-279. https://dx.doi.org/10.1515/jbcpp-2017-0121en_US
dc.identifier.issn0792-6855
dc.identifier.urihttps://hdl.handle.net/20.500.12511/861
dc.identifier.urihttps://dx.doi.org/10.1515/jbcpp-2017-0121
dc.description.abstractThe purpose of this study is to examine the dose-dependent effects of vitamin 1,25(OH)2D3 on apoptosis and oxidative stress. In this study, 50 male Balb/c mice were used as control and experiment groups. The mice were divided into 5 groups each consisting of 10 mice. Calcitriol was intraperitoneally administered as low dose, medium dose, medium-high dose and high dose Vitamin D groups (at 0.5, 1, 5 and 10 µg/kg, respectively), for three times a week during 14 days. At the end of the study, annexin V was measured by enzyme-linked immunosorbent assay method, and total antioxidant capacity and total oxidant status values were measured by colorimetric method in serum. Hematoxylin eosin staining was performed in liver tissues and periodic acid schiff staining was performed in kidney tissues. While comparing the results of medium-high dose (5 µg/kg) and high dose (10 µg/kg) Vitamin D administration to that of the control group, it was observed that serum antioxidant status and annexin V levels decreased and glomerular mesenchial matrix ratio increased in kidney (p<0.05). In addition to these findings, in the group receiving high dose Vitamin D (10 µg/kg), it was observed that the damage to the liver increased together with the the oxidative stress index values (p<0.05). As a result, this study was the first in the literature to report that use of high-dose Vitamin D (10 µg/kg) results in oxidant effect, rather than being an antioxidant, and causes severe histopathological toxicity in the liver and kidney.en_US
dc.language.isoengen_US
dc.publisherWalter de Gruyter GmbHen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectApoptosisen_US
dc.subjectCalcitriolen_US
dc.subjectOxidative Stressen_US
dc.subjectTotal Antioxidant Capacityen_US
dc.subjectTotal Oxidant Statusen_US
dc.titleDose-dependent effects of vitamin 1,25(OH)2D3 on oxidative stress and apoptosisen_US
dc.typearticleen_US
dc.relation.ispartofJournal of Basic and Clinical Physiology and Pharmacologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik ve Tıp Bilişimi Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.identifier.volume29en_US
dc.identifier.issue3en_US
dc.identifier.startpage271en_US
dc.identifier.endpage279en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1515/jbcpp-2017-0121en_US
dc.identifier.scopusqualityQ3en_US


Bu öğenin dosyaları:

Thumbnail

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster