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dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorBahadır Acıkara, Özlem
dc.contributor.authorKeskin, İlknur
dc.contributor.authorKırmızı, Neriman İpek
dc.contributor.authorÖzbilgin, Serkan
dc.contributor.authorÖz Ergene, Burçin
dc.contributor.authorKurtul, Ekin
dc.contributor.authorÖzrenk, Bade Cevriye
dc.contributor.authorTekin, Mehmet
dc.contributor.authorSaltan, Gülçin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:36Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:36Z
dc.date.issued2017en_US
dc.identifier.citationÖzbek, H., Bahadır Acıkara, Ö., Keskin, İ., Kırmızı, N. İ., Özbilgin, S., Öz Ergene, B. ... Saltan, G. (2017). Evaluation of hepatoprotective and antidiabetic activity of Alchemilla mollis. Biomedicine and Pharmacotherapy, 86, 172-176. https://dx.doi.org/10.1016/j.biopha.2016.12.005en_US
dc.identifier.issn0753-3322
dc.identifier.issn1950-6007
dc.identifier.urihttps://hdl.handle.net/20.500.12511/860
dc.identifier.urihttps://dx.doi.org/10.1016/j.biopha.2016.12.005
dc.description.abstractAlchemilla mollis (Buser) Rothm aerial part and root methanolic-water extracts were evaluated for their hepatoprotective activity on carbon tetrachloride induced hepatotoxicity and hypoglycemic activity on alloxan-induced diabetic mice. None of the tested extracts exhibited effects on blood glucose levels. However hepatoprotective activity results have revealed that serum ALT levels were significantly lowered by both the aerial part and root extracts at doses of 100 mg/kg and 200 mg/kg. Histopathological examination showed that A. mollis aerial parts and roots induced significant recovery from cellular damage; when compared to the carbon tetrachloride group, the most significant activity was observed with A. mollis aerial part extracts at a dose of 200 mg/kg. There is evidence of a hepatoprotective activity of A. mollis on the phenolic content of the plant, especially in the case of flavonoids, which have potent antioxidant properties.en_US
dc.language.isoengen_US
dc.publisherElsevier Masson SASen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAlchemilla Mollisen_US
dc.subjectAntidiabetic Activityen_US
dc.subjectHepatoprotective Activityen_US
dc.subjectMiceen_US
dc.subjectRatsen_US
dc.titleEvaluation of hepatoprotective and antidiabetic activity of Alchemilla mollisen_US
dc.typearticleen_US
dc.relation.journalBiomedicine and Pharmacotherapyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-8084-7855en_US
dc.authorid0000-0002-7059-1884en_US
dc.identifier.volume86en_US
dc.identifier.startpage172en_US
dc.identifier.endpage176en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.biopha.2016.12.005en_US


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