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dc.contributor.authorÇalıbaşı Koçal, Gizem
dc.contributor.authorÇakıcı, Çağrı
dc.contributor.authorToksöz, Feriha
dc.contributor.authorİnanç Sürer, Seniz
dc.contributor.authorSever, Tolga
dc.contributor.authorBaşbınar, Yasemin
dc.contributor.authorYiğitbaşı, Türkan
dc.date.accessioned2021-12-02T08:37:51Z
dc.date.available2021-12-02T08:37:51Z
dc.date.issued2021en_US
dc.identifier.citationÇalıbaşı Koçal, G., Çakıcı, Ç., Toksöz, F., İnanç Sürer, S., Sever, T., Başbınar, Y. ... Yiğitbaşı, T. (2021). Targeting the tumor metabolism by oxamate potentiates the impact of chemotherapeutics in colorectal cancer cells. Journal of Basic and Clinical Health Sciences, 5(3), 205-212. https://dx.doi.org/10.30621/jbachs.988996en_US
dc.identifier.issn2458-8938
dc.identifier.issn2564-7288
dc.identifier.urihttps://dx.doi.org/10.30621/jbachs.988996
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8598
dc.description.abstractPurpose: Cancer cells promote lactate formation via pyruvate rather than oxidative phosphorylation by programming their metabolism to maintain proliferation under the Warburg effect. It has shown that the altered metabolic phenotype with activation of lactate dehydrogenase-A in the cancer cell may affect survival, chemotherapy resistance, and metastasis. In this direction, studies are focusing on reprogramming cancer metabolism and increase the effectiveness of chemotherapy. In this study, the main aim was to target the Warburg phenotype via the inhibition of lactate dehydrogenase with the combination of sodium oxamate and current colorectal cancer treatment options such as 5-fluorouracil and irinotecan. Methods: The effect of chemotherapeutics on the cellular behavior was evaluated by real-time cytotoxicity and migration analysis systems, and metabolic phenotype was assessed by measuring lactate, lactate dehydrogenase expression, and reactive oxygen species levels. Results: According to the results, the viability and migration of colorectal cancer cells were significantly decreased with the combination of chemotherapeutics and sodium oxamate which decreases lactate levels. (C)onclusion: As a result, the combination of sodium oxamate with chemotherapeutics hinders the cancer cell viability and migration by changing metabolic phenotype with decreased lactate.en_US
dc.description.sponsorshipDokuz Eylul Universityen_US
dc.language.isoengen_US
dc.publisherDokuz Eylül University Institute of Health Sciencesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectColorectal Canceren_US
dc.subjectTumor Metabolismen_US
dc.subjectLactateen_US
dc.subjectSodium Oxamateen_US
dc.subjectWarburg Effecten_US
dc.titleTargeting the tumor metabolism by oxamate potentiates the impact of chemotherapeutics in colorectal cancer cellsen_US
dc.typearticleen_US
dc.relation.ispartofJournal of Basic and Clinical Health Sciencesen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.authorid0000-0002-8662-5284en_US
dc.authorid0000-0002-0675-1839en_US
dc.identifier.volume5en_US
dc.identifier.issue3en_US
dc.identifier.startpage205en_US
dc.identifier.endpage212en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.30621/jbachs.988996en_US
dc.identifier.trdizinid505623en_US


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