Basit öğe kaydını göster

dc.contributor.authorFreund, Jan Erik
dc.contributor.authorLiem, Esmee I.M.L.
dc.contributor.authorSavcı-Heijink, Cemile Dilara
dc.contributor.authorBaard, Joyce
dc.contributor.authorKamphuis, Guido Maarten
dc.contributor.authorde la Rosette, Jean J. M. C. H.
dc.contributor.authorde Bruin, Daniël Martijn
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:35Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:35Z
dc.date.issued2019en_US
dc.identifier.citationFreund, J. E., Liem, E. I.M.L., Savcı-Heijink, C. D., Baard, J., Kamphuis, G. M., de la Rosette, J. J. M. C. H. ve de Bruin, D. M. (2019). Confocal laser endomicroscopy for upper tract urothelial carcinoma: Validation of the proposed criteria and proposal of a scoring system for real-time tumor grading. World Journal of Urology, 37(10), 2155-2164. https://dx.doi.org/10.1007/s00345-019-02646-5en_US
dc.identifier.issn0724-4983
dc.identifier.issn1433-8726
dc.identifier.urihttps://hdl.handle.net/20.500.12511/855
dc.identifier.urihttps://dx.doi.org/10.1007/s00345-019-02646-5
dc.description.abstractPurpose: Confocal laser endomicroscopy (CLE) is a fluorescence-based fiber-optic imaging technique with the potential for intraoperative grading of upper tract urothelial carcinoma (UTUC). This study aims to (1) investigate the prevalence of the previously proposed CLE criteria for bladder cancer in papillary UTUC, (2) estimate the diagnostic value of CLE for UTUC grading and (3) propose a scoring system for a more quantifiable approach of CLE-based grading of UTUC. Materials and methods: Ureteroscopic CLE was performed in patients with UTUC. Following CLE imaging, co-localized biopsies were taken for histopathologic comparison. Postoperatively, two blinded raters assessed the CLE images. Results: Fifty-three papillary UTUCs (34 low grade and 19 high grade) were imaged with CLE in 36 patients. All the previously described CLE criteria were identifiable in varying proportions. After excluding 10 non-diagnostic recordings (5 low grade and 5 high grade) due to insufficient image quality, the histopathologic grade was correctly identified with CLE in 26 low-grade UTUCs (90%) and in 12 high-grade UTUCs (86%). The most prevalent CLE criteria with the highest diagnostic potential were cellular organization, morphology and cohesiveness of cells. A scoring system was proposed with these criteria, which yielded similar diagnostic accuracies. Conclusions: Based on the previously proposed criteria, CLE enables accurate grading of papillary UTUC at a non-diagnostic rate of 19%. The most prevalent CLE criteria with the highest diagnostic potential for grading of papillary UTUC are cellular organization, morphology and cohesiveness of cells. The proposed scoring system may simplify the assessment of CLE images for UTUC grading but external validation is required.en_US
dc.language.isoengen_US
dc.publisherSpringer Verlagen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectCLEen_US
dc.subjectConfocal Laser Endomicroscopyen_US
dc.subjectHistologic Gradingen_US
dc.subjectOptical Imagingen_US
dc.subjectUrothelial Carcinoma of the Upper Urinary Tracten_US
dc.subjectUTUCen_US
dc.titleConfocal laser endomicroscopy for upper tract urothelial carcinoma: Validation of the proposed criteria and proposal of a scoring system for real-time tumor gradingen_US
dc.typearticleen_US
dc.relation.ispartofWorld Journal of Urologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalıen_US
dc.authorid0000-0002-6308-1763en_US
dc.identifier.volume37en_US
dc.identifier.issue10en_US
dc.identifier.startpage2155en_US
dc.identifier.endpage2164en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s00345-019-02646-5en_US
dc.identifier.wosqualityQ1en_US
dc.identifier.scopusqualityQ1en_US


Bu öğenin dosyaları:

Thumbnail

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster

info:eu-repo/semantics/openAccess
Aksi belirtilmediği sürece bu öğenin lisansı: info:eu-repo/semantics/openAccess