dc.contributor.author | Sarıcaoğlu, Mevhibe | |
dc.contributor.author | Hanoğlu, Lütfü | |
dc.contributor.author | Toprak, Güven | |
dc.contributor.author | Helvacı Yılmaz, Nesrin | |
dc.contributor.author | Yuluğ, Burak | |
dc.date.accessioned | 2021-11-03T08:55:04Z | |
dc.date.available | 2021-11-03T08:55:04Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Sarıcaoğlu, M., Hanoğlu, L., Toprak, G., Helvacı Yılmaz, N. ve Yuluğ, B. (2022). The multifactorial role of pre-supplementary motor area stimulation in the freezing of gait: An alternative strategy to the classical drug-Target approach. Endocrine, Metabolic & Immune Disorders - Drug Targets, 22(5), 518-524. https://dx.doi.org/10.2174/1871530321666211014170107 | en_US |
dc.identifier.issn | 1871-5303 | |
dc.identifier.issn | 2212-3873 | |
dc.identifier.uri | https://dx.doi.org/10.2174/1871530321666211014170107 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/8553 | |
dc.description.abstract | Introduction: The pre-supplementary motor area (Pre-SMA) plays a pivotal role in the control of voluntary motor control and freezing of gait (FOG) pathophysiological mechanism. Here, we aimed to modulate if the pre-SMA would have beneficial effects on motor and behavioural outcomes in freezing of gait. To test this hypothesis, we examined the left pre-SMA stimulating effect of repetitive Transcranial Magnetic Stimulation (rTMS) on motor, cognitive and behavioural parameters in Parkinson's patients with FOG. Method: The study included 20 Parkinson's patients with FOG (3 females, 17 males) who received the left Pre-SMA rTMS procedure. The clinical assessments were performed on all patients at the baseline and the patients were re-evaluated under the same clinical conditions one week after the end of the sessions. Results & discussion: We found significant improvements in motor, cognitive and behavioural symptoms (p<0.05). The main finding of our study is that Pre-SMA is an attractive stimulation area leading to critical improvement of symptoms of Parkinson' s patients with FOG. Conclusion: The high-frequency rTMS stimulation over the left preSMA has a restorative effect on the motor, cognitive and behavioural symptoms of Parkinson' s patients with FOG. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Bentham Science Publishers | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Behavioural Symptoms | en_US |
dc.subject | Cognitive Symptoms | en_US |
dc.subject | Freezing of Gait | en_US |
dc.subject | Motor Symptoms | en_US |
dc.subject | Parkinson’s Disease | en_US |
dc.subject | Presupplementary Area | en_US |
dc.subject | Repetitive Transcranial Magnetic Stimulation | en_US |
dc.title | The multifactorial role of pre-supplementary motor area stimulation in the freezing of gait: An alternative strategy to the classical drug-Target approach | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Endocrine, Metabolic & Immune Disorders - Drug Targets | en_US |
dc.department | İstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Elektronörofizyoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-1289-4641 | en_US |
dc.authorid | 0000-0003-4292-5717 | en_US |
dc.authorid | 0000-0001-7566-1063 | en_US |
dc.identifier.volume | 22 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 518 | en_US |
dc.identifier.endpage | 524 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.2174/1871530321666211014170107 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.wos | 000887892500007 | en_US |
dc.identifier.scopus | 2-s2.0-85133103273 | en_US |
dc.identifier.pmid | 34649492 | en_US |
dc.identifier.scopusquality | Q3 | en_US |