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dc.contributor.authorErgan Şahin, Ayça
dc.contributor.authorKarasoy Yeşilada, Ayşin
dc.contributor.authorYalçın, Özben
dc.contributor.authorGüler, Eray Metin
dc.contributor.authorErbek, Harun
dc.contributor.authorKarabıyık, Damla
dc.date.accessioned2021-10-13T12:18:15Z
dc.date.available2021-10-13T12:18:15Z
dc.date.issued2021en_US
dc.identifier.citationErgan Şahin, A., Karasoy Yeşilada, A., Yalçın, Ö., Güler, E. M., Erbek, H. ve Karabıyık, D. (2021). Hydrogen-rich saline reduces tissue injury and improves skin flap survival on a rat hindlimb degloving injury model. Journal of Plastic, Reconstructive and Aesthetic Surgery, 74(9), 2095-2103. https://dx.doi.org/10.1016/j.bjps.2020.12.045en_US
dc.identifier.issn1748-6815
dc.identifier.issn1878-0539
dc.identifier.urihttps://dx.doi.org/10.1016/j.bjps.2020.12.045
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8440
dc.description.abstractBackground: Degloving injuries represent a challenge in plastic surgery. The aim of this study is to acknowledge the protective effects of hydrogen-rich saline (HRS) solution on a rat hindlimb degloved skin flap. Methods: Twenty-one Sprague–Dawley rats were divided into three groups (control, saline and HRS). Degloving injury model was established, and flaps were sutured back following 5 min of ischemia. The control group did not receive any treatment. The saline group received intraperitoneal physiological saline (10 ml/kg) and the HRS group received intraperitoneal HRS solution (10 ml/kg) postoperatively and daily for 5 days after the operation. Skin samples were obtained for histological, immunohistochemical and biochemical evaluations. Results: Inflammation was lower in the HRS compared with saline (p = 0.02) and control (p = 0.004) groups. Edema was lower in the HRS compared with saline (p = 0.02) and control (p = 0.001) groups. Malondialdehyde (MDA) level was lower in the HRS than the control group (p = 0.01). Total antioxidant level was higher in the HRS compared with saline (p = 0.009) and control (p = 0.03) groups. Total oxidant level was lower in the HRS than the control group (p = 0.02). Oxidative stress index was lower in the HRS compared with saline (p = 0.001) and control (p = 0.0001) groups`. Vascular proliferation was higher in the HRS compared with the control group (p = 0.01). Conclusion: Repeated HRS injections after trauma increased the viability of skin flap in rat degloving injury model by decreasing local tissue injury, due to its antioxidant, anti-inflammatory and angiogenic effects.en_US
dc.language.isoengen_US
dc.publisherElsevier Science Ltden_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectDegloving Injuryen_US
dc.subjectFlapen_US
dc.subjectHydrogen-Rich Salineen_US
dc.subjectIschemia/Reperfusion Injuryen_US
dc.titleHydrogen-rich saline reduces tissue injury and improves skin flap survival on a rat hindlimb degloving injury modelen_US
dc.typearticleen_US
dc.relation.journalJournal of Plastic, Reconstructive and Aesthetic Surgeryen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalıen_US
dc.authorid0000-0003-0908-1719en_US
dc.identifier.volume74en_US
dc.identifier.issue9en_US
dc.identifier.startpage2095en_US
dc.identifier.endpage2103en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.bjps.2020.12.045en_US


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