dc.contributor.author | Bayram, Nihan | |
dc.contributor.author | Yaman, Yöntem | |
dc.contributor.author | Özdilli, Kürşat | |
dc.contributor.author | Telhan, Leyla | |
dc.contributor.author | Nepesov, Serdar | |
dc.contributor.author | Bilgen, Hülya | |
dc.contributor.author | Elli, Murat | |
dc.contributor.author | Behar, Sude Sema | |
dc.contributor.author | Anak, Sema | |
dc.date.accessioned | 2021-10-11T08:19:24Z | |
dc.date.available | 2021-10-11T08:19:24Z | |
dc.date.issued | 2021 | en_US |
dc.identifier.citation | Bayram, N., Yaman, Y., Özdilli, K., Telhan, L., Nepesov, S., Bilgen, H. ... Anak, S. (2021). Clinical efficacy of ruxolitinib monotherapy and haploidentical hematopoeitic stem cell transplantation in a child with philadelphia chromosome-like relapsed/refractory acute lymphoblastic leukemia. Pediatric Transplantation, 25(4). https://dx.doi.org/10.1111/petr.14024 | en_US |
dc.identifier.issn | 1397-3142 | |
dc.identifier.issn | 1399-3046 | |
dc.identifier.uri | https://dx.doi.org/10.1111/petr.14024 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/8410 | |
dc.description.abstract | Introduction (Ph-like) ALL is a subset of leukemia which has a gene expression profile similar to Ph+disease, but without the presence of BCR-ABL1 translocation.
Case description We reported an exceptional case of a child with relapsed Ph-like ALL with IKZF1 gene deletion treated with high-dose ruxolitinib as monotherapy, after multi-agent chemotherapy. He remains in continued MRD-negative leukemia remission with full donor chimerism at 12 months post-HSCT.
Discussion The circumstance that makes our case featured is the usage of ruxolitinib as monotherapy. This report, we believe, is a pioneering report for a frequent disease with a high risk of failure for the outcome. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | JAK Inhibitors | en_US |
dc.subject | Philadelphia-Like ALL | en_US |
dc.subject | Refractory ALL | en_US |
dc.subject | Stem Cell Transplantation | en_US |
dc.title | Clinical efficacy of ruxolitinib monotherapy and haploidentical hematopoeitic stem cell transplantation in a child with philadelphia chromosome-like relapsed/refractory acute lymphoblastic leukemia | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Pediatric Transplantation | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-9688-5223 | en_US |
dc.authorid | 0000-0002-9710-8653 | en_US |
dc.authorid | 0000-0002-7129-5024 | en_US |
dc.authorid | 0000-0003-0037-7636 | en_US |
dc.authorid | 0000-0002-4551-5433 | en_US |
dc.authorid | 0000-0002-7424-8688 | en_US |
dc.authorid | 0000-0002-0476-5452 | en_US |
dc.authorid | 0000-0001-9629-0783 | en_US |
dc.authorid | 0000-0001-8489-7449 | en_US |
dc.identifier.volume | 25 | en_US |
dc.identifier.issue | 4 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1111/petr.14024 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.scopusquality | Q2 | en_US |