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dc.contributor.authorTamahkar, Emel
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorÖzbaş, Zehra
dc.contributor.authorİzbudak, Burçin
dc.contributor.authorYarımçan, Filiz
dc.contributor.authorBoran, Filiz
dc.contributor.authorBal Öztürk, Ayça
dc.date.accessioned2021-10-07T09:42:53Z
dc.date.available2021-10-07T09:42:53Z
dc.date.issued2021en_US
dc.identifier.citationTamahkar, E., Özkahraman, B., Özbaş, Z., İzbudak, B., Yarımçan, F., Boran, F. ... Bal Öztürk, A. (2021). Aloe vera-based antibacterial porous sponges for wound dressing applications. Journal of Porous Materials, 28(3), 741-750. https://dx.doi.org/10.1007/s10934-020-01029-1en_US
dc.identifier.issn1380-2224
dc.identifier.issn1573-4854
dc.identifier.urihttps://dx.doi.org/10.1007/s10934-020-01029-1
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8385
dc.description.abstractThe antibacterial sponges with high macroporosity, high interconnectivity and high biocompatibility is a significant concern for wound healing applications. In this work, novel Aloe vera (AV) based sponges were developed via subsequent lyophilization with further chemical crosslinking throughout the double network sponges. Single network was composed of gelatin-sodium alginate (G-SA) while the double network using gelatin-sodium alginate- sodium hyaluronate (G-SA-HA) was produced with the addition of hyaluronic acid solution into the gelatin-sodium alginate matrix. Lastly, Aloe vera as the bioactive agent was fabricated throughout the gelatin-sodium alginate-sodium hyaluronate matrix. The AV-based sponges demonstrated large pores with high interconnectivity. The swelling degree of the AV-based sponges were higher than that of G-SA and G-SA-HA sponges. The release of AV from the sponges reached an equilibrium value after 24 h showing a more controlled release at pH 5.5 than at pH 7.4. AV-based sponges showed antibacterial activity against Staphylococcus aureus, Enterococcus faecalis, Streptococcus pneumoniae and Bacillus cereus and displayed any cytotoxicity against Mesenchymal stem cells.en_US
dc.description.sponsorshipHitit University ; Hitit University Scientific and Tecnical Application and Research Centeren_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAloe Veraen_US
dc.subjectAntibacterial Spongeen_US
dc.subjectHydrogelen_US
dc.subjectWound Dressingsen_US
dc.titleAloe vera-based antibacterial porous sponges for wound dressing applicationsen_US
dc.typearticleen_US
dc.relation.journalJournal of Porous Materialsen_US
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalıen_US
dc.authorid0000-0001-8267-0435en_US
dc.identifier.volume28en_US
dc.identifier.issue3en_US
dc.identifier.startpage741en_US
dc.identifier.endpage750en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s10934-020-01029-1en_US


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