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dc.contributor.authorDanış, Nilay
dc.contributor.authorErtınmaz Özkan, Ayşegül
dc.contributor.authorKarataş, Fatih
dc.contributor.authorÇakıcı, Çağrı
dc.contributor.authorYiğitbaşı, Türkan
dc.contributor.authorÖzkan Sevencan, Nurhayat
dc.contributor.authorKayhan, Burçak
dc.date.accessioned2021-10-04T08:13:14Z
dc.date.available2021-10-04T08:13:14Z
dc.date.issued2021en_US
dc.identifier.citationDanış, N., Ertınmaz Özkan, A., Karataş, F., Çakıcı, Ç., Yiğitbaşı, T., Özkan Sevencan, N. ... Kayhan, B. (2021). The importance of antioxidant status in gastric intestinal metaplasia. Journal of Medical Biochemistry, 40(4), 378-383. https://dx.doi.org/10.5937/jomb0-29349en_US
dc.identifier.issn1452-8258
dc.identifier.issn1452-8266
dc.identifier.urihttps://dx.doi.org/10.5937/jomb0-29349
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8351
dc.description.abstractBackground: Oxidative stress status in different cancer types was investigated before, but not studied in gastric intestinal metaplasia to the best of our knowledge. Purpose of this study is to examine whether there is a difference between oxidative stress status in patients with intestinal metaplasia (IM) compared to individuals without IM, we compared the serum levels of disulfide (SS), total thiol (TT) and native thiol (NT). Methods: This was a prospective, non-randomized casecontrol study including 67 patients with histopathologically confirmed IM and 60 individuals demographically matched in terms of age, gender, BMI, smoking status, and chronic diseases as control group. Results: The mean NT, TT and NT to TT (NT/TT) ratios were statistically significantly higher in IM group compared to controls ((351.71 ± 81.9 _mol/L vs. 271.82 ± 54.13 _mol/L, p=0.000), (391.5 ± 92.69 _mol/L vs. 308.59 ± 55.53 _mol/L, p=0.000) and (0.89 ± 0.6 vs. 0.87 ± 0.29, p=0.022), respectively). The mean SS to TT (SS/TT) ratio was significantly lower in IM group than control group (0.050 ± 0.31 vs. 0.060 ± 0.014, P=0.022). Median SS and mean SS/NT ratio was similar in both groups (16.3 (3.3-78) vs. 18.3 (10-32.7), p=0.271 and 0.055 ± 0.041 vs. 0.070 ± 0.019, p=0.068, respectively). In ROC analysis, cut off value of SS/NT for IM was found 0.062, in regression analysis, SS/NT <0.062 was found as an independently prognostic marker for IM (OR, 2.38; 95%CI: 1.168-4.865, P=0.017). Conclusions: SS/NT ratio lower than 0.062 was found as an independently prognostic marker for IM. This ratio could help to distinguish which patients should be followed closely for gastric cancer.en_US
dc.description.abstractUvod: Status oksidativnog stresa kod različitih vrsta karcinoma istražen je ranije, ali nije proučavan u intestinalnoj metaplaziji želuca prema našem najboljem znanju. Svrha ove studije je da ispita da li postoji razlika između statusa oksidativnog stresa kod pacijenata sa intestinalnom metaplazijom (IM) u poređenju sa osobama bez IM, tako što su upoređeni nivoi serumskog disulfida (SS), ukupnog tiola (TT) i nativnog tiola (NT). Metode: Ovo je bila prospektivna, nerandomizirana studija slučaja i kontrole, koja je obuhvatala 67 pacijenata sa histo patološki potvrđenim IM i 60 osoba demografski podudarnih u pogledu starosti, pola, BMI-a, statusa pušenja i hroničnih bolesti kao kontrolna grupa. Rezultati: Srednji odnosi NT, TT i NT prema TT (NT/TT) bili su statistički značajno veći u IM grupi u poređenju sa kontrolama (351,71 ± 81,9 mol/L naspram 271,82 ± 54,13 mol/L, p=0,000), (391,5 ± 92,69 mol/L na - suprot 308,59 ± 55,53 mol/L, p=0,000) i (0,89 ± 0,6 naspram 0,87 ± 0,29, p=0,022), respektivno. Srednji odnos SS prema TT (SS/TT) bio je značajno niži u IM grupi od kontrolne grupe (0,050 ± 0,31 naspram 0,060 ± 0,014, P=0,022). Medijana SS i srednji odnos SS/NT bili su slični u obe grupe 16,3 (3,3-78) naspram 18,3 (10-32,7), p=0,271 i 0,055 ± 0,041 naspram 0,070 ± 0,019, p=0,068, respektivno). U ROC analizi utvrđena je granična vrednost SS/NT za IM 0,062, u regresionoj analizi SS/NT <0,062 kao nezavisno prognostički marker za IM (OR, 2,38; 95% CI: 1,168-4,865, P=0,017). Zaključak: SS/NT odnos niži od 0,062 pronađen je kao nezavisno prognostički marker za IM. Ovaj odnos bi mogao da pomogne da se dijagnostikuju pacijenti kod kojih treba pažljivo pratiti rak želuca.en_US
dc.language.isoengen_US
dc.publisherSociety of Medical Biochemists of Serbiaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntestinal Metaplasiaen_US
dc.subjectOxidative Stressen_US
dc.subjectTiolen_US
dc.subjectDisulphideen_US
dc.subjectIntestinalna Metaplazijaen_US
dc.subjectOksidativni Stresen_US
dc.subjectTiolen_US
dc.subjectDisulfiden_US
dc.titleThe importance of antioxidant status in gastric intestinal metaplasiaen_US
dc.title.alternativeZnačaj antioksidantnog statusa u gastrične intestinalne metaplazijeen_US
dc.typearticleen_US
dc.relation.journalJournal of Medical Biochemistryen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.authorid0000-0002-8662-5284en_US
dc.authorid0000-0002-0675-1839en_US
dc.identifier.volume40en_US
dc.identifier.issue4en_US
dc.identifier.startpage378en_US
dc.identifier.endpage383en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.5937/jomb0-29349en_US


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