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dc.contributor.authorCoşkunpınar, Ender
dc.contributor.authorAkkaya, Nergiz
dc.contributor.authorYıldız, Pınar
dc.contributor.authorMüşteri Oltulu, Yasemin
dc.contributor.authorAynacı, Engin
dc.contributor.authorİşbir, Turgay
dc.contributor.authorYaylım, İlhan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:30Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:30Z
dc.date.issued2014en_US
dc.identifier.citationCoşkunpınar, E., Akkaya, N., Yıldız, P., Müşteri Oltulu, Y., Aynacı, E., İşbir, T. ... Yaylım, İ. (2014). The significance of HSP90AA1, HSP90AB1 and HSP90B1 gene polymorphisms in a Turkish population with non-small cell lung cancer. Anticancer Research, 34(2), 753-758.en_US
dc.identifier.issn0250-7005
dc.identifier.issn1791-7530
dc.identifier.urihttps://hdl.handle.net/20.500.12511/810
dc.description.abstractBackground/Aim: Heat-shock proteins (HSPs) are molecular chaperones which modify the structures and interactions of other proteins. The aim of our study was to investigate HSP90AA1, HSP90AB1 and HSP90B1 gene polymorphisms in patients with non-small cell lung cancer (NSCLC). Materials and Methods: Ninety-seven patients with NSCLC and 97 healthy controls were included in the study. Real-time polymerase chain reaction was used for genotyping. Results: The frequency of mutant CC genotype for HSP90AA1 (rs4947C/T), mutant AA genotype for HSP90AB1 (rs13296A/G) and mutant CC genotype for HSP90B1 (rs2070908 C/G) was significantly higher in the patient group than in controls (p=0.019, p=0.004 and p=0.036, respectively). The frequency of patients with homozygote mutant allele was also significantly higher than that of controls and possessing of the mutant genotype increased the risk for disease by approximately 2.9, 4.8, 1.9 for HSP90AA1, HSP90AB1 and HSP90B1, respectively. The present study appears to be the first of its kind to report data on these gene polymorphisms in patients with NSCLC in the Turkish population.en_US
dc.description.sponsorshipIstanbul Universityen_US
dc.language.isoengen_US
dc.publisherInternational Institute of Anticancer Researchen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectHSP90AA1en_US
dc.subjectHSP90AB1en_US
dc.subjectHSP90B1en_US
dc.subjectNSCLCen_US
dc.subjectSNPsen_US
dc.subjectTurkish Populationen_US
dc.titleThe significance of HSP90AA1, HSP90AB1 and HSP90B1 gene polymorphisms in a Turkish population with non-small cell lung canceren_US
dc.typearticleen_US
dc.relation.journalAnticancer Researchen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalıen_US
dc.identifier.volume34en_US
dc.identifier.issue2en_US
dc.identifier.startpage753en_US
dc.identifier.endpage757en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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